tetano
Editor, Senior Moderator
Int J Infect Dis
. 2022 Apr 29;S1201-9712(22)00257-0.
doi: 10.1016/j.ijid.2022.04.057. Online ahead of print.
An autopsy case of COVID-19-like acute respiratory distress syndrome after mRNA-1273 SARS-CoV-2 vaccination
Yukihiro Yoshimura[SUP] 1 [/SUP], Hiroaki Sasaki[SUP] 2 [/SUP], Nobuyuki Miyata[SUP] 2 [/SUP], Kazuhito Miyazaki[SUP] 3 [/SUP], Koji Okudela[SUP] 4 [/SUP], Yoko Tateishi[SUP] 5 [/SUP], Hiroyuki Hayashi[SUP] 5 [/SUP], Ai Kawana-Tachikawa[SUP] 6 [/SUP], Hiromichi Iwashita[SUP] 4 [/SUP], Kazuho Maeda[SUP] 7 [/SUP], Yoko Ihama[SUP] 7 [/SUP], Yasuyoshi Hatayama[SUP] 8 [/SUP], Akihide Ryo[SUP] 8 [/SUP], Natsuo Tachikawa[SUP] 2 [/SUP]
Affiliations
Abstract
We report the first case with COVID-19-like acute respiratory distress syndrome following mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. An 88-year-old woman developed dyspnea several hours after vaccination with the second dose of mRNA-1273. She was hospitalized on day 9 due to worsening dyspnea. Chest computed tomography showed bilateral ground-glass opacities and consolidations, mainly in the peripheral lung areas. Repeat polymerase chain reaction tests for SARS-CoV-2 were negative though serum level of antibodies against spike protein was elevated extremely. Her condition did not improve with high-dose corticosteroids and high-flow nasal cannula oxygen therapy; she died on day 18. Autopsy findings revealed very early-phase diffuse alveolar damage in the whole lung without other lung diseases. The clinical and pathological findings suggested vaccine-induced acute respiratory distress syndrome. Serological and pathological tests might be useful to differentiate the disease from COVID-19.
Keywords: COVID-19; acute respiratory distress syndrome; autopsy; vaccine.
. 2022 Apr 29;S1201-9712(22)00257-0.
doi: 10.1016/j.ijid.2022.04.057. Online ahead of print.
An autopsy case of COVID-19-like acute respiratory distress syndrome after mRNA-1273 SARS-CoV-2 vaccination
Yukihiro Yoshimura[SUP] 1 [/SUP], Hiroaki Sasaki[SUP] 2 [/SUP], Nobuyuki Miyata[SUP] 2 [/SUP], Kazuhito Miyazaki[SUP] 3 [/SUP], Koji Okudela[SUP] 4 [/SUP], Yoko Tateishi[SUP] 5 [/SUP], Hiroyuki Hayashi[SUP] 5 [/SUP], Ai Kawana-Tachikawa[SUP] 6 [/SUP], Hiromichi Iwashita[SUP] 4 [/SUP], Kazuho Maeda[SUP] 7 [/SUP], Yoko Ihama[SUP] 7 [/SUP], Yasuyoshi Hatayama[SUP] 8 [/SUP], Akihide Ryo[SUP] 8 [/SUP], Natsuo Tachikawa[SUP] 2 [/SUP]
Affiliations
- PMID: 35500794
- DOI: 10.1016/j.ijid.2022.04.057
Abstract
We report the first case with COVID-19-like acute respiratory distress syndrome following mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. An 88-year-old woman developed dyspnea several hours after vaccination with the second dose of mRNA-1273. She was hospitalized on day 9 due to worsening dyspnea. Chest computed tomography showed bilateral ground-glass opacities and consolidations, mainly in the peripheral lung areas. Repeat polymerase chain reaction tests for SARS-CoV-2 were negative though serum level of antibodies against spike protein was elevated extremely. Her condition did not improve with high-dose corticosteroids and high-flow nasal cannula oxygen therapy; she died on day 18. Autopsy findings revealed very early-phase diffuse alveolar damage in the whole lung without other lung diseases. The clinical and pathological findings suggested vaccine-induced acute respiratory distress syndrome. Serological and pathological tests might be useful to differentiate the disease from COVID-19.
Keywords: COVID-19; acute respiratory distress syndrome; autopsy; vaccine.