tetano
Editor, Senior Moderator
Int J Biol Sci. 2020 Mar 15;16(10):1718-1723. doi: 10.7150/ijbs.45123. eCollection 2020.
Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2.
Zhou G[SUP]1,[/SUP][SUP]2[/SUP], Zhao Q[SUP]1,[/SUP][SUP]2[/SUP].
Author information
Abstract
A newly identified novel coronavirus (SARS-CoV-2) is causing pneumonia-associated respiratory syndrome across the world. Epidemiology, genomics, and pathogenesis of the SARS-CoV-2 show high homology with that of SARS-CoV. Current efforts are focusing on development of specific antiviral drugs. Therapeutic neutralizing antibodies (NAbs) against SARS-CoV-2 will be greatly important therapeutic agents for the treatment of coronavirus disease 2019 (COVID-19). Herein, the host immune responses against SARS-CoV discussed in this review provide implications for developing NAbs and understanding clinical interventions against SARS-CoV-2. Further, we describe the benefits, challenges and considerations of NAbs against SARS-CoV-2. Although many challenges exist, NAbs still offer a therapeutic option to control the current pandemic and the possible re-emergence of the virus in the future, and their development therefore remains a high priority.
? The author(s).
KEYWORDS:
COVID-19; Neutralizing antibody; SARS-CoV-2; severe acute respiratory syndrome
PMID:32226289PMCID:PMC7098029DOI:10.7150/ijbs.45123
Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2.
Zhou G[SUP]1,[/SUP][SUP]2[/SUP], Zhao Q[SUP]1,[/SUP][SUP]2[/SUP].
Author information
Abstract
A newly identified novel coronavirus (SARS-CoV-2) is causing pneumonia-associated respiratory syndrome across the world. Epidemiology, genomics, and pathogenesis of the SARS-CoV-2 show high homology with that of SARS-CoV. Current efforts are focusing on development of specific antiviral drugs. Therapeutic neutralizing antibodies (NAbs) against SARS-CoV-2 will be greatly important therapeutic agents for the treatment of coronavirus disease 2019 (COVID-19). Herein, the host immune responses against SARS-CoV discussed in this review provide implications for developing NAbs and understanding clinical interventions against SARS-CoV-2. Further, we describe the benefits, challenges and considerations of NAbs against SARS-CoV-2. Although many challenges exist, NAbs still offer a therapeutic option to control the current pandemic and the possible re-emergence of the virus in the future, and their development therefore remains a high priority.
? The author(s).
KEYWORDS:
COVID-19; Neutralizing antibody; SARS-CoV-2; severe acute respiratory syndrome
PMID:32226289PMCID:PMC7098029DOI:10.7150/ijbs.45123