tetano
Editor, Senior Moderator
Int Immunopharmacol
. 2024 Jun 11:137:112419.
doi: 10.1016/j.intimp.2024.112419. Online ahead of print. Immune checkpoint inhibitors and SARS-CoV2 infection
Samaneh Abdolmohammadi-Vahid[SUP] 1 [/SUP], Behzad Baradaran[SUP] 2 [/SUP], Ian M Adcock[SUP] 3 [/SUP], Esmaeil Mortaz[SUP] 4 [/SUP]
Affiliations
Infection with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) triggers coronavirus disease 2019 (COVID-19), which predominantly targets the respiratory tract. SARS-CoV-2 infection, especially severe COVID-19, is associated with dysregulated immune responses against the virus, including exaggerated inflammatory responses known as the cytokine storm, together with lymphocyte and NK cell dysfunction known as immune cell exhaustion. Overexpression of negative immune checkpoints such as PD-1 and CTLA-4 plays a considerable role in the dysfunction of immune cells upon SARS-CoV-2 infection. Blockade of these checkpoints has been suggested to improve the clinical outcome of COVID-19 patients by promoting potent immune responses against the virus. In the current review, we provide an overview of the potential of checkpoint inhibitors to induce potent immune responses against SARS-CoV-2 and improving the clinical outcome of severe COVID-19 patients.
Keywords: COVID-19; ICIs; SARS-CoV-2; T lymphocyte.
. 2024 Jun 11:137:112419.
doi: 10.1016/j.intimp.2024.112419. Online ahead of print. Immune checkpoint inhibitors and SARS-CoV2 infection
Samaneh Abdolmohammadi-Vahid[SUP] 1 [/SUP], Behzad Baradaran[SUP] 2 [/SUP], Ian M Adcock[SUP] 3 [/SUP], Esmaeil Mortaz[SUP] 4 [/SUP]
Affiliations
- PMID: 38865755
- DOI: 10.1016/j.intimp.2024.112419
Infection with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) triggers coronavirus disease 2019 (COVID-19), which predominantly targets the respiratory tract. SARS-CoV-2 infection, especially severe COVID-19, is associated with dysregulated immune responses against the virus, including exaggerated inflammatory responses known as the cytokine storm, together with lymphocyte and NK cell dysfunction known as immune cell exhaustion. Overexpression of negative immune checkpoints such as PD-1 and CTLA-4 plays a considerable role in the dysfunction of immune cells upon SARS-CoV-2 infection. Blockade of these checkpoints has been suggested to improve the clinical outcome of COVID-19 patients by promoting potent immune responses against the virus. In the current review, we provide an overview of the potential of checkpoint inhibitors to induce potent immune responses against SARS-CoV-2 and improving the clinical outcome of severe COVID-19 patients.
Keywords: COVID-19; ICIs; SARS-CoV-2; T lymphocyte.