tetano
Editor, Senior Moderator
Int Immunopharmacol
. 2020 Jun 28;86:106738.
doi: 10.1016/j.intimp.2020.106738. Online ahead of print.
Immune and bioinformatics identification of T cell and B cell epitopes in the protein structure of SARS-CoV-2: A systematic review
Zahra Noorimotlagh[SUP] 1 [/SUP], Chiman Karami[SUP] 2 [/SUP], Seyyed Abbas Mirzaee[SUP] 1 [/SUP], Mohammadreza Kaffashian[SUP] 3 [/SUP], Sanaz Mami[SUP] 4 [/SUP], Mahdieh Azizi[SUP] 5 [/SUP]
Affiliations
Abstract
The beginning of 2020 was marked as the emergence of a COVID-19 outbreak caused by a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, there is no vaccine or approved treatment for this infectious virus so the invention of an efficient vaccine is certainly a high priority. Some studies have employed several techniques to facilitate the combination of the immunoinformatics approach and comparative genomic approach in order to determine the potential peptides for designing the T-cell epitope-based peptide vaccine using the 2019-nCoV envelope protein as a target. Via screening the bioimmunoinformatic SARS-CoV2 derived B-cell and T-cell epitopes within the basic immunogenic of SARS-CoV2 proteins, we presented a set of inferred B-cell and T-cell epitopes from the spike (S) and nucleocapsid (N) proteins with high antigenicity and without allergenic property or toxic effects. Our findings provide a screened set of epitopes that can be introduced as potential targets for developing peptide vaccines against the SARS-CoV-2 virus.
Keywords: B-cell epitopes; Bioinformatics; COVID-19; SARS-CoV-2; T-cell epitopes.
. 2020 Jun 28;86:106738.
doi: 10.1016/j.intimp.2020.106738. Online ahead of print.
Immune and bioinformatics identification of T cell and B cell epitopes in the protein structure of SARS-CoV-2: A systematic review
Zahra Noorimotlagh[SUP] 1 [/SUP], Chiman Karami[SUP] 2 [/SUP], Seyyed Abbas Mirzaee[SUP] 1 [/SUP], Mohammadreza Kaffashian[SUP] 3 [/SUP], Sanaz Mami[SUP] 4 [/SUP], Mahdieh Azizi[SUP] 5 [/SUP]
Affiliations
- PMID: 32683296
- DOI: 10.1016/j.intimp.2020.106738
Abstract
The beginning of 2020 was marked as the emergence of a COVID-19 outbreak caused by a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, there is no vaccine or approved treatment for this infectious virus so the invention of an efficient vaccine is certainly a high priority. Some studies have employed several techniques to facilitate the combination of the immunoinformatics approach and comparative genomic approach in order to determine the potential peptides for designing the T-cell epitope-based peptide vaccine using the 2019-nCoV envelope protein as a target. Via screening the bioimmunoinformatic SARS-CoV2 derived B-cell and T-cell epitopes within the basic immunogenic of SARS-CoV2 proteins, we presented a set of inferred B-cell and T-cell epitopes from the spike (S) and nucleocapsid (N) proteins with high antigenicity and without allergenic property or toxic effects. Our findings provide a screened set of epitopes that can be introduced as potential targets for developing peptide vaccines against the SARS-CoV-2 virus.
Keywords: B-cell epitopes; Bioinformatics; COVID-19; SARS-CoV-2; T-cell epitopes.