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Insights Into Environmental Conditions That Affect Highly Pathogenic Bird Flu Virus Survival

tetano

Editor, Senior Moderator
On the eve of the 2010-11 influenza flu season, scientists and engineers have identified the environmental conditions and surfaces that could enable a highly pathogenic (H5N1) bird flu virus to survive for prolonged periods of time - at least two weeks and up to two months. Among them: The virus appears to thrive at cooler temperatures and low humidity. The study, which could lead to new strategies for preventing the flu virus from spreading, appears in ACS' Environmental Science & Technology, a semi-monthly journal.

Joseph Wood and colleagues note that the highly pathogenic (H5N1) avian influenza virus so far has been rare but dangerous in humans, with mortality rates of about 60 percent. Although the H5N1 virus may spread to humans by direct contact with infected birds or other virus-contaminated material, health experts are concerned that the virus could evolve to develop the ability to spread from person to person, and cause serious outbreaks. However, there is little information on how different environmental conditions and materials affect H5N1's survival.

The scientists investigated the ability of a strain of highly pathogenic H5N1 originating from Viet Nam to survive on a variety of materials under different environmental conditions, including changes in temperature, humidity, and simulated sunlight. The materials included glass, wood, steel, soil, and chicken feces. They found that H5N1 survived longer (up to two weeks) at cooler temperatures - around 39 degrees Fahrenheit - but lasted only up to one day at room temperature. The virus also tends to persist at low humidity and no sunlight and on certain surfaces, including glass and steel. Although when exposed to simulated sunlight, the virus survived longer on soil and chicken feces compared to the other materials. It could potentially survive for up to two months on those materials, they estimate. At low temperatures and low humidity, the virus actually survived longer on steel, glass, and soil than in chicken feces, a common source for spreading the virus. "Measures taken to contain and inactivate the virus, especially in these areas or conditions, may be warranted," the article notes.

Article:
"Environmental Persistence of a Highly Pathogenic Avian Influenza (H5N1) Virus"

Source:
Michael Bernstein
American Chemical Society


http://www.medicalnewstoday.com/articles/204609.php
 
Re: Insights Into Environmental Conditions That Affect Highly Pathogenic Bird Flu Virus Survival

Environmental Persistence of a Highly Pathogenic Avian Influenza (H5N1) Virus
Joseph P. Wood, Young W. Choi, Daniel J. Chappie, James V. Rogers, and Jonathan Z. Kaye
Environ. Sci. Technol., 2010, 44 (19), pp 7515?7520
Publication Date (Web): September 3, 2010 (Article)
DOI: 10.1021/es1016153
Human cases of disease caused by highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype are rare, yet characterized with a mortality rate of approximately 60%. Tests were conducted to determine the environmental persistence of an HPAI (H5N1) virus on four materials (glass, wood, galvanized metal, and topsoil) that could act as fomites or harbor the virus. Test coupons were inoculated with the virus and exposed to one of five environmental conditions that included changes in temperature, relative humidity, and simulated sunlight. At time periods up to 13 days, the virus was extracted from each coupon, and quantified via cytopathic effects on Madin−Darby canine kidney cells. The virus was most persistent under the low temperature condition, with less than 1 log reduction on glass and steel after 13 days at low relative humidity. Thus, at these conditions, the virus would be expected to persist appreciably beyond 13 days.

http://pubs.acs.org/doi/abs/10.1021/es1016153?prevSearch=h5n1&searchHistoryKey=
 
Re: Insights Into Environmental Conditions That Affect Highly Pathogenic Bird Flu Virus Survival

less than 1 log reduction on glass and steel after 13 days at low relative humidity. Thus, at these conditions, the virus would be expected to persist appreciably beyond 13 days.
 
Re: Insights Into Environmental Conditions That Affect Highly Pathogenic Bird Flu Virus Survival

I still wonder what causes it to become nonviable. Does the shell crack when it dries out? It survives for quite some time in water and mud, eventially becoming nonviable; does the pH damage the shell?
 
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