tetano
Editor, Senior Moderator
Uirusu. 2015;65(1):127-34. doi: 10.2222/jsv.65.127.
[h=1]Innate recognition of influenza virus and vaccine development.[/h] Ichinohe T[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Understanding the mechanisms by which influenza viruses are recognized by the innate immune system to elicit a protective adaptive immune response is essential for the development of effective vaccines. We have demonstrated that synthetic double-stranded RNA poly(I:C) is an effective adjuvant for intranasal influenza vaccine. Furthermore, we found that influenza virus activated the NLR family, pyrin domain-containing 3 (NLRP3) inflammasome via its M2 protein. Inflammasome activation in the lung coupled with priming signals from the commensal microbiota in the gut are essential for the generation of influenza virus-specific adaptive immune responses. These results provide a useful basis for developing effective vaccines against influenza viruses.
PMID: 26923967 [PubMed - in process]
[h=1]Innate recognition of influenza virus and vaccine development.[/h] Ichinohe T[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Understanding the mechanisms by which influenza viruses are recognized by the innate immune system to elicit a protective adaptive immune response is essential for the development of effective vaccines. We have demonstrated that synthetic double-stranded RNA poly(I:C) is an effective adjuvant for intranasal influenza vaccine. Furthermore, we found that influenza virus activated the NLR family, pyrin domain-containing 3 (NLRP3) inflammasome via its M2 protein. Inflammasome activation in the lung coupled with priming signals from the commensal microbiota in the gut are essential for the generation of influenza virus-specific adaptive immune responses. These results provide a useful basis for developing effective vaccines against influenza viruses.
PMID: 26923967 [PubMed - in process]