tetano
Editor, Senior Moderator
J Virol. 2012 Mar 7. [Epub ahead of print]
Influenza viruses expressing chimeric hemagglutinins: Globular head and stalk domains derived from different subtypes.
Hai R, Krammer F, Tan GS, Pica N, Eggink D, Maamary J, Margine I, Albrecht RA, Palese P.
Source
Department of Microbiology.
Abstract
The influenza virus hemagglutinin molecule possesses a globular head domain that mediates receptor binding, and a stalk domain at the membrane proximal region. We generated functional influenza viruses expressing chimeric hemagglutinins encompassing a variety of globular head and stalk combinations, not only from different hemagglutinin subtypes but also from different hemagglutinin phylogenetic groups. These chimeric recombinant viruses possess growth properties similar to those of wild-type influenza viruses and can be used as reagents to measure domain-specific antibodies in virological and immunological assays.
PMID:
22398287
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22398287
Influenza viruses expressing chimeric hemagglutinins: Globular head and stalk domains derived from different subtypes.
Hai R, Krammer F, Tan GS, Pica N, Eggink D, Maamary J, Margine I, Albrecht RA, Palese P.
Source
Department of Microbiology.
Abstract
The influenza virus hemagglutinin molecule possesses a globular head domain that mediates receptor binding, and a stalk domain at the membrane proximal region. We generated functional influenza viruses expressing chimeric hemagglutinins encompassing a variety of globular head and stalk combinations, not only from different hemagglutinin subtypes but also from different hemagglutinin phylogenetic groups. These chimeric recombinant viruses possess growth properties similar to those of wild-type influenza viruses and can be used as reagents to measure domain-specific antibodies in virological and immunological assays.
PMID:
22398287
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22398287