tetano
Editor, Senior Moderator
Vopr Virusol. 2012 Mar-Apr;57(2):20-3.
[Influenza virus reproduction in the endothelial cells of human blood vessels].
[Article in Russian]
[No authors listed]
Abstract
The current epidemic strains of the influenza subtypes Y5N1, H3N2, and H1N1 can be reproduced in the cultured human endothelial EAhy926 cells with an infective activity of 3.0-4.5 Ig TCD50. These findings were confirmed by the analysis of the autopsy material from patients who had died from influenza during the 2009-2010 epidemic, which showed influenza virus HA and NP proteins in the pulmonary blood vascular endothelium. The results obtained reflect a new aspect of the pathogenesis of influenza, which is important for the design of antiviral agents and for the development of combination therapy.
PMID:
22834142
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22834142
[Influenza virus reproduction in the endothelial cells of human blood vessels].
[Article in Russian]
[No authors listed]
Abstract
The current epidemic strains of the influenza subtypes Y5N1, H3N2, and H1N1 can be reproduced in the cultured human endothelial EAhy926 cells with an infective activity of 3.0-4.5 Ig TCD50. These findings were confirmed by the analysis of the autopsy material from patients who had died from influenza during the 2009-2010 epidemic, which showed influenza virus HA and NP proteins in the pulmonary blood vascular endothelium. The results obtained reflect a new aspect of the pathogenesis of influenza, which is important for the design of antiviral agents and for the development of combination therapy.
PMID:
22834142
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22834142