tetano
Editor, Senior Moderator
J Infect Dis. 2014 Nov 21. pii: jiu650. [Epub ahead of print]
Influenza Vaccine Effectiveness in Households with Children during the 2012-2013 Season: Assessments of Prior Vaccination and Serologic Susceptibility.
Ohmit SE1, Petrie JG1, Malosh RE1, Fry AM2, Thompson MG2, Monto AS1.
Author information
Abstract
BACKGROUND:
There are recognized needs to identify determinants of influenza vaccine effectiveness (VE) including the effect of repeated annual vaccination.
METHODS:
We recruited 321 households with 1426 members, including 833 children, and followed them during the 2012-2013 influenza season; specimens were collected from subjects with reported acute respiratory illnesses. We estimated the effectiveness of documented influenza vaccination in preventing laboratory-confirmed influenza in adjusted Cox proportional hazards models. Pre-season susceptibility hemagglutination-inhibition (HAI) antibody titers were determined on a subset of subjects.
RESULTS:
Influenza was identified in 76 (24%) households and 111 (8%) individuals. VE point estimates indicated significant protection in adults (48%, 95% CI, 1 to 72), similar protection in children 9-17 years (49%, CI -16 to 78), but no evidence of effectiveness in children <9 years (-4%, 95% CI, -110 to 49). Lower VE was observed in those vaccinated in both the current and prior seasons compared with those vaccinated in the current season only; susceptibility titers against type A but not type B, were consistent with this observation. Residual protection from vaccination in the prior season was indicated by both VE and serologic results.
CONCLUSIONS:
Prior vaccination appears to modify VE by both residual protection and reduced vaccine response.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID:
25416812
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25416812
Influenza Vaccine Effectiveness in Households with Children during the 2012-2013 Season: Assessments of Prior Vaccination and Serologic Susceptibility.
Ohmit SE1, Petrie JG1, Malosh RE1, Fry AM2, Thompson MG2, Monto AS1.
Author information
Abstract
BACKGROUND:
There are recognized needs to identify determinants of influenza vaccine effectiveness (VE) including the effect of repeated annual vaccination.
METHODS:
We recruited 321 households with 1426 members, including 833 children, and followed them during the 2012-2013 influenza season; specimens were collected from subjects with reported acute respiratory illnesses. We estimated the effectiveness of documented influenza vaccination in preventing laboratory-confirmed influenza in adjusted Cox proportional hazards models. Pre-season susceptibility hemagglutination-inhibition (HAI) antibody titers were determined on a subset of subjects.
RESULTS:
Influenza was identified in 76 (24%) households and 111 (8%) individuals. VE point estimates indicated significant protection in adults (48%, 95% CI, 1 to 72), similar protection in children 9-17 years (49%, CI -16 to 78), but no evidence of effectiveness in children <9 years (-4%, 95% CI, -110 to 49). Lower VE was observed in those vaccinated in both the current and prior seasons compared with those vaccinated in the current season only; susceptibility titers against type A but not type B, were consistent with this observation. Residual protection from vaccination in the prior season was indicated by both VE and serologic results.
CONCLUSIONS:
Prior vaccination appears to modify VE by both residual protection and reduced vaccine response.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID:
25416812
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25416812