tetano
Editor, Senior Moderator
Vaccine. 2011 Dec 1. [Epub ahead of print]
Influenza vaccine effectiveness among adult patients in a University of Lyon hospital (2004-2009).
Amour S, Voirin N, Regis C, Bouscambert-Duchamp M, Comte B, Copp?r? B, Pires-Cronenberger S, Lina B, Vanhems P.
Source
Universit? de Lyon, Universit? de Lyon 1, CNRS UMR 5558, Laboratoire de Biom?trie et Biologie Evolutive, Lyon, France.
Abstract
The aim of this study was to estimate influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza among hospitalized patients. A case-control investigation was based on the prospective surveillance of influenza-like illness (ILI) during five flu seasons. We compared influenza-positive cases and influenza-negative controls. Unadjusted overall IVE was 62% (95% confidence interval 24% to 81%). We found that IVE was lower during the 2004-05 flu season (11%; 95% CI -232% to 76%) when the vaccine and circulating viruses were mismatched. Expansion of the study to other hospitals could provide IVE estimates earlier in the season, for different age groups and emerging virus strains.
Copyright ? 2011. Published by Elsevier Ltd.
PMID:
22138212
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22138212
Influenza vaccine effectiveness among adult patients in a University of Lyon hospital (2004-2009).
Amour S, Voirin N, Regis C, Bouscambert-Duchamp M, Comte B, Copp?r? B, Pires-Cronenberger S, Lina B, Vanhems P.
Source
Universit? de Lyon, Universit? de Lyon 1, CNRS UMR 5558, Laboratoire de Biom?trie et Biologie Evolutive, Lyon, France.
Abstract
The aim of this study was to estimate influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza among hospitalized patients. A case-control investigation was based on the prospective surveillance of influenza-like illness (ILI) during five flu seasons. We compared influenza-positive cases and influenza-negative controls. Unadjusted overall IVE was 62% (95% confidence interval 24% to 81%). We found that IVE was lower during the 2004-05 flu season (11%; 95% CI -232% to 76%) when the vaccine and circulating viruses were mismatched. Expansion of the study to other hospitals could provide IVE estimates earlier in the season, for different age groups and emerging virus strains.
Copyright ? 2011. Published by Elsevier Ltd.
PMID:
22138212
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22138212