tetano
Editor, Senior Moderator
Curr Allergy Asthma Rep. 2017 Oct 5;17(11):78. doi: 10.1007/s11882-017-0749-3.
[h=1]Influenza Vaccination in Patients with Common Variable Immunodeficiency (CVID).[/h] Mieves JF[SUP]1[/SUP], Wittke K[SUP]1[/SUP], Freitag H[SUP]1[/SUP], Volk HD[SUP]1,[/SUP][SUP]2[/SUP], Scheibenbogen C[SUP]1[/SUP], Hanitsch LG[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]PURPOSE OF REVIEW:[/h] Vaccination against influenza in patients with primary antibody deficiency is recommended. Common variable immunodeficiency (CVID) is the most frequent and clinically relevant antibody deficiency disease and is by definition characterized by an impaired vaccination response. The purpose of this review is to present the current knowledge of humoral and cellular vaccine response to influenza in CVID patients.
[h=4]RECENT FINDINGS:[/h] Studies conducted in CVID patients demonstrated an impaired humoral response upon influenza vaccination. Data on cellular immune response are in part conflicting, with two out of three studies showing responses similar to healthy controls. Available data suggest a benefit from influenza vaccination in CVID patients. Therefore, annual influenza vaccination in patients and their close household contacts is recommended.
[h=4]KEYWORDS:[/h] Common variable immunodeficiency; Influenza; Primary antibody deficiency; Vaccination
PMID: 28983790 DOI: 10.1007/s11882-017-0749-3
[h=1]Influenza Vaccination in Patients with Common Variable Immunodeficiency (CVID).[/h] Mieves JF[SUP]1[/SUP], Wittke K[SUP]1[/SUP], Freitag H[SUP]1[/SUP], Volk HD[SUP]1,[/SUP][SUP]2[/SUP], Scheibenbogen C[SUP]1[/SUP], Hanitsch LG[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]PURPOSE OF REVIEW:[/h] Vaccination against influenza in patients with primary antibody deficiency is recommended. Common variable immunodeficiency (CVID) is the most frequent and clinically relevant antibody deficiency disease and is by definition characterized by an impaired vaccination response. The purpose of this review is to present the current knowledge of humoral and cellular vaccine response to influenza in CVID patients.
[h=4]RECENT FINDINGS:[/h] Studies conducted in CVID patients demonstrated an impaired humoral response upon influenza vaccination. Data on cellular immune response are in part conflicting, with two out of three studies showing responses similar to healthy controls. Available data suggest a benefit from influenza vaccination in CVID patients. Therefore, annual influenza vaccination in patients and their close household contacts is recommended.
[h=4]KEYWORDS:[/h] Common variable immunodeficiency; Influenza; Primary antibody deficiency; Vaccination
PMID: 28983790 DOI: 10.1007/s11882-017-0749-3