tetano
Editor, Senior Moderator
Influenza Other Respir Viruses
. 2025 Nov;19(11):e70185.
doi: 10.1111/irv.70185. Obesity in Recovery From Influenza-Like Illness and Effectiveness of Oseltamivir
Oanh Ngoc Nguyen[SUP] 1 2 3 [/SUP], Nathaly Garzón-Orjuela[SUP] 1 [/SUP], Alike W van der Velden[SUP] 4 [/SUP], Christopher C Butler[SUP] 5 [/SUP], Akke Vellinga[SUP] 1 [/SUP]
Affiliations
Background: Results from observational studies have shown that obesity has a mild to moderate association with influenza-like illness (ILI) severity and hospitalization risk. Using data from the ALIC[SUP]4[/SUP]E Randomized Clinical Trial (RCT), this study investigated the relationship between obesity and ILI severity, time to recovery, and oseltamivir effectiveness in the obese population.
Methods: A total of 2622 adults (≥ 18 years old) from the ALIC[SUP]4[/SUP]E RCT were categorized by body mass index (BMI) into under/normal weight (BMI < 25 kg/m[SUP]2[/SUP]), overweight (BMI ≥ 25 kg/m[SUP]2[/SUP] and < 30 kg/m[SUP]2[/SUP]), and obesity (BMI ≥ 30 kg/m[SUP]2[/SUP]). ILI symptom severity, time to recovery, and oseltamivir effectiveness were assessed across these weight groups.
Results: At presentation, ILI symptom severity was not different between weight groups. However, time to recovery was longer for obese patients compared to under/normal weight patients, with adjusted HR 0.88 (95% CI 0.79-0.99). The mean time to recovery was 6.6 days (95% CI 6.0-7.1) for obese patients, 6.2 days (95% CI 5.8-6.6) for overweight, and 5.7 days (95% CI 5.4-6.1) for under/normal weight patients. Obese patients had similar benefits from oseltamivir treatment compared to under/normal weight patients, with an average of 0.8 days gained from oseltamivir (95% CI 0.7-1) and 0.5 days (95% CI 0.4-0.7), respectively.
Conclusions: ILI symptom severity at presentation was equally distributed between the three weight groups. However, their time to recovery was approximately 1 day longer compared to under/normal weight patients. The effectiveness of oseltamivir appears to be similar between the two groups.
Keywords: influenza‐like illness; obesity; oseltamivir; recovery adults; severity.
. 2025 Nov;19(11):e70185.
doi: 10.1111/irv.70185. Obesity in Recovery From Influenza-Like Illness and Effectiveness of Oseltamivir
Oanh Ngoc Nguyen[SUP] 1 2 3 [/SUP], Nathaly Garzón-Orjuela[SUP] 1 [/SUP], Alike W van der Velden[SUP] 4 [/SUP], Christopher C Butler[SUP] 5 [/SUP], Akke Vellinga[SUP] 1 [/SUP]
Affiliations
- PMID: 41211613
- PMCID: PMC12598495
- DOI: 10.1111/irv.70185
Background: Results from observational studies have shown that obesity has a mild to moderate association with influenza-like illness (ILI) severity and hospitalization risk. Using data from the ALIC[SUP]4[/SUP]E Randomized Clinical Trial (RCT), this study investigated the relationship between obesity and ILI severity, time to recovery, and oseltamivir effectiveness in the obese population.
Methods: A total of 2622 adults (≥ 18 years old) from the ALIC[SUP]4[/SUP]E RCT were categorized by body mass index (BMI) into under/normal weight (BMI < 25 kg/m[SUP]2[/SUP]), overweight (BMI ≥ 25 kg/m[SUP]2[/SUP] and < 30 kg/m[SUP]2[/SUP]), and obesity (BMI ≥ 30 kg/m[SUP]2[/SUP]). ILI symptom severity, time to recovery, and oseltamivir effectiveness were assessed across these weight groups.
Results: At presentation, ILI symptom severity was not different between weight groups. However, time to recovery was longer for obese patients compared to under/normal weight patients, with adjusted HR 0.88 (95% CI 0.79-0.99). The mean time to recovery was 6.6 days (95% CI 6.0-7.1) for obese patients, 6.2 days (95% CI 5.8-6.6) for overweight, and 5.7 days (95% CI 5.4-6.1) for under/normal weight patients. Obese patients had similar benefits from oseltamivir treatment compared to under/normal weight patients, with an average of 0.8 days gained from oseltamivir (95% CI 0.7-1) and 0.5 days (95% CI 0.4-0.7), respectively.
Conclusions: ILI symptom severity at presentation was equally distributed between the three weight groups. However, their time to recovery was approximately 1 day longer compared to under/normal weight patients. The effectiveness of oseltamivir appears to be similar between the two groups.
Keywords: influenza‐like illness; obesity; oseltamivir; recovery adults; severity.