tetano
Editor, Senior Moderator
Open Forum Infect Dis. 2014 Jun 10;1(1)
fu031. doi: 10.1093/ofid/ofu031. eCollection 2014.
[h=1]Influenza hospitalizations among american indian/alaska native people and in the United States general population.[/h] Gounder PP[SUP]1[/SUP], Callinan LS[SUP]2[/SUP], Holman RC[SUP]2[/SUP], Cheng PY[SUP]3[/SUP], Bruce MG[SUP]1[/SUP], Redd JT[SUP]4[/SUP], Steiner CA[SUP]5[/SUP], Bresee J[SUP]3[/SUP], Hennessy TW[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Historically, American Indian/Alaska Native (AI/AN) people have experienced a disproportionate burden of infectious disease morbidity compared with the general US population. We evaluated whether a disparity in influenza hospitalizations exists between AI/AN people and the general US population.
[h=4]METHODS:[/h] We used Indian Health Service hospital discharge data (2001-2011) for AI/AN people and 13 State Inpatient Databases (2001-2008) to provide a comparison to the US population. Hospitalization rates were calculated by respiratory year (July-June). Influenza-specific hospitalizations were defined as discharges with any influenza diagnoses. Influenza-associated hospitalizations were calculated using negative binomial regression models that incorporated hospitalization and influenza laboratory surveillance data.
[h=4]RESULTS:[/h] The mean influenza-specific hospitalization rate/100 000 persons/year during the 2001-2002 to 2007-2008 respiratory years was 18.6 for AI/AN people and 15.6 for the comparison US population. The age-adjusted influenza-associated hospitalization rate for AI/AN people (98.2; 95% confidence interval [CI], 51.6-317.8) was similar to the comparison US population (58.2; CI, 34.7-172.2). By age, influenza-associated hospitalization rates were significantly higher among AI/AN infants (<1 year) (1070.7; CI, 640.7-2969.5) than the comparison US infant population (210.2; CI, 153.5-478.5).
[h=4]CONCLUSIONS:[/h] American Indian/Alaska Native people had higher influenza-specific hospitalization rates than the comparison US population; a significant influenza-associated hospitalization rate disparity was detected only among AI/AN infants because of the wide CIs inherent to the model. Taken together, the influenza-specific and influenza-associated hospitalization rates suggest that AI/AN people might suffer disproportionately from influenza illness compared with the general US population.
[h=4]KEYWORDS:[/h] American Indian; epidemiology; healthcare disparities; influenza
PMID: 25734102 [PubMed] PMCID: PMC4324209 Free PMC Article
fu031. doi: 10.1093/ofid/ofu031. eCollection 2014.[h=1]Influenza hospitalizations among american indian/alaska native people and in the United States general population.[/h] Gounder PP[SUP]1[/SUP], Callinan LS[SUP]2[/SUP], Holman RC[SUP]2[/SUP], Cheng PY[SUP]3[/SUP], Bruce MG[SUP]1[/SUP], Redd JT[SUP]4[/SUP], Steiner CA[SUP]5[/SUP], Bresee J[SUP]3[/SUP], Hennessy TW[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Historically, American Indian/Alaska Native (AI/AN) people have experienced a disproportionate burden of infectious disease morbidity compared with the general US population. We evaluated whether a disparity in influenza hospitalizations exists between AI/AN people and the general US population.
[h=4]METHODS:[/h] We used Indian Health Service hospital discharge data (2001-2011) for AI/AN people and 13 State Inpatient Databases (2001-2008) to provide a comparison to the US population. Hospitalization rates were calculated by respiratory year (July-June). Influenza-specific hospitalizations were defined as discharges with any influenza diagnoses. Influenza-associated hospitalizations were calculated using negative binomial regression models that incorporated hospitalization and influenza laboratory surveillance data.
[h=4]RESULTS:[/h] The mean influenza-specific hospitalization rate/100 000 persons/year during the 2001-2002 to 2007-2008 respiratory years was 18.6 for AI/AN people and 15.6 for the comparison US population. The age-adjusted influenza-associated hospitalization rate for AI/AN people (98.2; 95% confidence interval [CI], 51.6-317.8) was similar to the comparison US population (58.2; CI, 34.7-172.2). By age, influenza-associated hospitalization rates were significantly higher among AI/AN infants (<1 year) (1070.7; CI, 640.7-2969.5) than the comparison US infant population (210.2; CI, 153.5-478.5).
[h=4]CONCLUSIONS:[/h] American Indian/Alaska Native people had higher influenza-specific hospitalization rates than the comparison US population; a significant influenza-associated hospitalization rate disparity was detected only among AI/AN infants because of the wide CIs inherent to the model. Taken together, the influenza-specific and influenza-associated hospitalization rates suggest that AI/AN people might suffer disproportionately from influenza illness compared with the general US population.
[h=4]KEYWORDS:[/h] American Indian; epidemiology; healthcare disparities; influenza
PMID: 25734102 [PubMed] PMCID: PMC4324209 Free PMC Article