tetano
Editor, Senior Moderator
Med Clin (Barc). 2010 Apr 21. [Epub ahead of print]
[Influenza A, pregnancy and neuraminidase inhibitors.]
[Article in Spanish]
Montan? E, Lecumberri J, Pedro-Botet ML.
Servicio de Farmacolog?a Cl?nica, Hospital Universitari Germans Trias i Pujol, Universitat Aut?noma de Barcelona, Badalona, Barcelona, Espa?a.
Abstract
Following the explosion of the influenza A pandemic (H1N1) during the first semester of 2009, oseltamivir and zanamivir were used as the treatment of choice in the absence of rigorous clinical studies demonstrating their efficacy in the treatment and prophylaxis of this disease. Knowledge of seasonal influenza, flu pandemics and particularly the H1N1, which produces more severe infection and a higher mortality rate during pregnancy, led to the use of antiviral treatment despite the scarcity of clinical studies on their efficacy and effectiveness, mainly due to the influence of the media. This study reviewed the experimental and clinical studies performed on the safety of oseltamivir and zanamivir in pregnancy. Likewise, the recommendations made by the different health care and governmental authorities as well as other institutions and scientific and health care organizations on the therapeutic management and prophylaxis of influenza A 2009 in pregnant women were reviewed. Copyright ? 2010 Elsevier Espa?a, S.L. All rights reserved.
PMID: 20416906 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20416906
[Influenza A, pregnancy and neuraminidase inhibitors.]
[Article in Spanish]
Montan? E, Lecumberri J, Pedro-Botet ML.
Servicio de Farmacolog?a Cl?nica, Hospital Universitari Germans Trias i Pujol, Universitat Aut?noma de Barcelona, Badalona, Barcelona, Espa?a.
Abstract
Following the explosion of the influenza A pandemic (H1N1) during the first semester of 2009, oseltamivir and zanamivir were used as the treatment of choice in the absence of rigorous clinical studies demonstrating their efficacy in the treatment and prophylaxis of this disease. Knowledge of seasonal influenza, flu pandemics and particularly the H1N1, which produces more severe infection and a higher mortality rate during pregnancy, led to the use of antiviral treatment despite the scarcity of clinical studies on their efficacy and effectiveness, mainly due to the influence of the media. This study reviewed the experimental and clinical studies performed on the safety of oseltamivir and zanamivir in pregnancy. Likewise, the recommendations made by the different health care and governmental authorities as well as other institutions and scientific and health care organizations on the therapeutic management and prophylaxis of influenza A 2009 in pregnant women were reviewed. Copyright ? 2010 Elsevier Espa?a, S.L. All rights reserved.
PMID: 20416906 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20416906