Giuseppe
Emeritus
Influenza A(H1N1) virus resistance to oseltamivir - 2008 influenza season, southern hemisphere [WHO]
Influenza A(H1N1) virus resistance to oseltamivir - 2008 influenza season, southern hemisphere
14 October 2008
[Full PDF text: http://www.who.int/csr/disease/influenza/H1N1200801013.pdf ]
During the weeks 37?40 (7 September ? 4 October), influenza activity in the southern hemisphere continued to decline. In New Zealand, influenza activity declined from widespread to local, with influenza B virus circulating.
Activity was also low in the rest of the world ? declining influenza activity (H1, H3) was reported from Hong Kong SAR, China, sporadic influenza activity was detected in Argentina (A,B), Cameroon (B), Canada (A, B), Chile (A, B), Poland (A), South Africa (B), the United Kingdom (A) and the United States of America (A,B).
WHO has received several reports from National Influenza Centres (NIC) in the southern hemisphere regarding influenza A(H1N1) virus resistance to oseltamivir.
In South Africa, a total of 306 A(H1N1) viruses have been isolated during the 2008 influenza season as of 6 October.
Of those, 225 isolates have been tested for oseltamivir resistance by the National Institute of Communicable Diseases (NICD) and 100% were found to be resistant to oseltamivir by genotypic analysis.
Only one of these 225 patients was receiving oseltamivir at the time of sampling, and no unusual clinical features or underlying conditions were found.
In Australia, 47 of 59, Argentina, 15 of 33, Chile, 10 of 79, Kenya, 1 of 4, New Caledonia, 7 of 7, New Zealand, 2 of 2, and Uruguay 13 of 16 A(H1N1) viruses analysed showed the specific neuraminidase mutation (H274Y) associated with oseltamivir resistance, respectively.
WHO has also received reports from NICs in other parts of the world; in Algeria, 4 of 13, Canada, 1of 2, Ghana 5 of 13, Guatemala, 4 of 5, Honduras, 5 of 8, Ivory Coast, 2 of 5, the Netherlands, 1 of 2, Nigeria, 1 of 1, Senegal 10 of 10 and the United States of America, 3 of 7 A(H1N1) viruses tested were found to be resistant, respectively.
WHO is collecting global data about this phenomenon from multiple laboratories participating in Global Influenza Surveillance Network.
Data from European countries participating in EISS were provided by the EISS and VirGil project. This summary table will be updated regularly (every four weeks).
Oseltamivir resistance results were based on phenotypic and/or genotypic analyses.
For background and summary until week 24, 2008, see Influenza A(H1N1) virus resistance to oseltamivir, Last quarter 2007 to first quarter 2008, Preliminary summary and future plans
http://www.who.int/csr/disease/influenza/oseltamivir_summary/en/index.html
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Influenza A(H1N1) virus resistance to oseltamivir - 2008 influenza season, southern hemisphere
14 October 2008
[Full PDF text: http://www.who.int/csr/disease/influenza/H1N1200801013.pdf ]
During the weeks 37?40 (7 September ? 4 October), influenza activity in the southern hemisphere continued to decline. In New Zealand, influenza activity declined from widespread to local, with influenza B virus circulating.
Activity was also low in the rest of the world ? declining influenza activity (H1, H3) was reported from Hong Kong SAR, China, sporadic influenza activity was detected in Argentina (A,B), Cameroon (B), Canada (A, B), Chile (A, B), Poland (A), South Africa (B), the United Kingdom (A) and the United States of America (A,B).
WHO has received several reports from National Influenza Centres (NIC) in the southern hemisphere regarding influenza A(H1N1) virus resistance to oseltamivir.
In South Africa, a total of 306 A(H1N1) viruses have been isolated during the 2008 influenza season as of 6 October.
Of those, 225 isolates have been tested for oseltamivir resistance by the National Institute of Communicable Diseases (NICD) and 100% were found to be resistant to oseltamivir by genotypic analysis.
Only one of these 225 patients was receiving oseltamivir at the time of sampling, and no unusual clinical features or underlying conditions were found.
In Australia, 47 of 59, Argentina, 15 of 33, Chile, 10 of 79, Kenya, 1 of 4, New Caledonia, 7 of 7, New Zealand, 2 of 2, and Uruguay 13 of 16 A(H1N1) viruses analysed showed the specific neuraminidase mutation (H274Y) associated with oseltamivir resistance, respectively.
WHO has also received reports from NICs in other parts of the world; in Algeria, 4 of 13, Canada, 1of 2, Ghana 5 of 13, Guatemala, 4 of 5, Honduras, 5 of 8, Ivory Coast, 2 of 5, the Netherlands, 1 of 2, Nigeria, 1 of 1, Senegal 10 of 10 and the United States of America, 3 of 7 A(H1N1) viruses tested were found to be resistant, respectively.
WHO is collecting global data about this phenomenon from multiple laboratories participating in Global Influenza Surveillance Network.
Data from European countries participating in EISS were provided by the EISS and VirGil project. This summary table will be updated regularly (every four weeks).
Oseltamivir resistance results were based on phenotypic and/or genotypic analyses.
For background and summary until week 24, 2008, see Influenza A(H1N1) virus resistance to oseltamivir, Last quarter 2007 to first quarter 2008, Preliminary summary and future plans
http://www.who.int/csr/disease/influenza/oseltamivir_summary/en/index.html
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<table style="width: auto;"><tbody><tr><td>
</td></tr><tr><td style="font-family: arial,sans-serif; font-size: 11px; text-align: right;">From TABLES</td></tr></tbody></table><table style="width: auto;"><tbody><tr><td>
</td></tr><tr><td style="font-family: arial,sans-serif; font-size: 11px; text-align: right;">From TABLES</td></tr></tbody></table><table style="width: auto;"><tbody><tr><td>
</td></tr><tr><td style="font-family: arial,sans-serif; font-size: 11px; text-align: right;">From TABLES</td></tr></tbody></table><table style="width: auto;"><tbody><tr><td>
</td></tr><tr><td style="font-family: arial,sans-serif; font-size: 11px; text-align: right;">From TABLES</td></tr></tbody></table>--