tetano
Editor, Senior Moderator
Public Health. 2015 May 27. pii: S0033-3506(15)00187-0. doi: 10.1016/j.puhe.2015.04.013. [Epub ahead of print]
[h=1]Influenza A(H1N1)pdm09 infection in pregnant and non-pregnant women hospitalized in Singapore, May - December 2009.[/h] Lim C[SUP]1[/SUP], Ang LW[SUP]2[/SUP], Tey SH[SUP]1[/SUP], James L[SUP]1[/SUP], Kanagalingam D[SUP]3[/SUP], Su LL[SUP]4[/SUP], Tan HK[SUP]3[/SUP], Yong EL[SUP]4[/SUP], Lim ML[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] The aim of this study was to compare the demographic and clinical characteristics of pregnant women and non-pregnant women of childbearing age hospitalized with laboratory-confirmed influenza A(H1N1)pdm09 infection in Singapore, and to assess whether pregnancy was a risk factor associated with the development of influenza-related complications.
[h=4]STUDY DESIGN:[/h] Retrospective observational study.
[h=4]METHODS:[/h] We retrospectively identified and collected information from available medical records of all women admitted to three tertiary hospitals between 26 May 2009 and 31 December 2009 with laboratory-confirmed influenza A(H1N1)pdm09 infection who were either pregnant or non-pregnant and of childbearing age between 15 and 50 years.
[h=4]RESULTS:[/h] A total of 222 women, of whom 81 (36.5%) were pregnant, were hospitalized during the study period. Pregnant women were significantly more likely to be hospitalized with influenza A(H1N1)pdm09 infection than non-pregnant women of childbearing age (relative risk 26.3; 95% confidence interval: 20.1-34.6). Among those hospitalized, the proportion of pregnant women having at least one underlying medical condition that could predispose them to influenza-related complications was significantly lower than that of non-pregnant women (32.1% versus 56.0%, P < 0.001). The median time from onset of symptoms to administration of anti-viral drugs was significantly shorter among pregnant women than among non-pregnant women (three days versus five days, P < 0.001). The median length of stay in hospital was also significantly shorter among pregnant women than that of non-pregnant women (two days versus three days, P = 0.002). About 4.9% of pregnant women developed influenza-related complications, compared with 12.8% among non-pregnant women (P = 0.066).
[h=4]CONCLUSIONS:[/h] Pregnant women with influenza A(H1N1)pdm09 infection were at a higher risk of hospitalization. Upon hospitalization, they were not at a higher risk of developing influenza-related complications.
Copyright ? 2015 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] A(H1N1)pdm09; Complications; Hospitalization; Pregnancy; Singapore
PMID: 26026347 [PubMed - as supplied by publisher]
[h=1]Influenza A(H1N1)pdm09 infection in pregnant and non-pregnant women hospitalized in Singapore, May - December 2009.[/h] Lim C[SUP]1[/SUP], Ang LW[SUP]2[/SUP], Tey SH[SUP]1[/SUP], James L[SUP]1[/SUP], Kanagalingam D[SUP]3[/SUP], Su LL[SUP]4[/SUP], Tan HK[SUP]3[/SUP], Yong EL[SUP]4[/SUP], Lim ML[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] The aim of this study was to compare the demographic and clinical characteristics of pregnant women and non-pregnant women of childbearing age hospitalized with laboratory-confirmed influenza A(H1N1)pdm09 infection in Singapore, and to assess whether pregnancy was a risk factor associated with the development of influenza-related complications.
[h=4]STUDY DESIGN:[/h] Retrospective observational study.
[h=4]METHODS:[/h] We retrospectively identified and collected information from available medical records of all women admitted to three tertiary hospitals between 26 May 2009 and 31 December 2009 with laboratory-confirmed influenza A(H1N1)pdm09 infection who were either pregnant or non-pregnant and of childbearing age between 15 and 50 years.
[h=4]RESULTS:[/h] A total of 222 women, of whom 81 (36.5%) were pregnant, were hospitalized during the study period. Pregnant women were significantly more likely to be hospitalized with influenza A(H1N1)pdm09 infection than non-pregnant women of childbearing age (relative risk 26.3; 95% confidence interval: 20.1-34.6). Among those hospitalized, the proportion of pregnant women having at least one underlying medical condition that could predispose them to influenza-related complications was significantly lower than that of non-pregnant women (32.1% versus 56.0%, P < 0.001). The median time from onset of symptoms to administration of anti-viral drugs was significantly shorter among pregnant women than among non-pregnant women (three days versus five days, P < 0.001). The median length of stay in hospital was also significantly shorter among pregnant women than that of non-pregnant women (two days versus three days, P = 0.002). About 4.9% of pregnant women developed influenza-related complications, compared with 12.8% among non-pregnant women (P = 0.066).
[h=4]CONCLUSIONS:[/h] Pregnant women with influenza A(H1N1)pdm09 infection were at a higher risk of hospitalization. Upon hospitalization, they were not at a higher risk of developing influenza-related complications.
Copyright ? 2015 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] A(H1N1)pdm09; Complications; Hospitalization; Pregnancy; Singapore
PMID: 26026347 [PubMed - as supplied by publisher]