tetano
Editor, Senior Moderator
Infect Drug Resist
. 2021 Apr 9;14:1363-1373.
doi: 10.2147/IDR.S305509. eCollection 2021.
Complications of Cardiovascular Events in Patients Hospitalized with Influenza-Related Pneumonia
Liang Chen[SUP] 1 [/SUP], Xiudi Han[SUP] 2 [/SUP], YanLi Li[SUP] 3 [/SUP], Chunxiao Zhang[SUP] 4 [/SUP], Xiqian Xing[SUP] 5 [/SUP]
Affiliations
Abstract
Purpose: Influenza virus infections are a key cause of community-acquired pneumonia (CAP). Cardiovascular events (CVEs) are common among CAP and influenza patients, but there have been few population-based studies of influenza-related pneumonia (Flu-p) patients published to date.
Methods: A retrospective analysis of 1191 immunocompetent hospitalized adult Flu-p patients from January 2012 to December 2018 in five teaching hospitals in China was conducted.
Results: A total of 24.6% (293/1191) of patients developed at least one form of CVE-related complication while hospitalized. In a multivariate logistic regression analysis, hypertension, cerebrovascular disease, coronary artery disease, preexisting heart failure, systolic blood pressure <90 mmHg, respiratory rates ?30 breaths/min, a lymphocyte count <0.8?10[SUP]9[/SUP]/L, PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] <300 mmHg, and systemic corticosteroid administration were independently associated with the incidence of CVEs; while early neuraminidase inhibitor treatment and angiotensin converting enzyme inhibitors/angiotensin II receptor blocker treatment were associated with a lower risk of CVEs. After controlling for potential confounding variables, we determined that CVEs were linked to a higher risk of 30-day mortality (OR 3.307, 95% CI 2.198-4.975, p < 0.001) in Flu-p patients.
Conclusion: CVE-related complications are common among hospitalized Flu-p patients and are associated with negative patient outcomes. Clarifying these CVE-related risk factors can aid in their clinical prevention and management.
Keywords: cardiovascular event; clinical outcome; influenza-related pneumonia; risk factor.
. 2021 Apr 9;14:1363-1373.
doi: 10.2147/IDR.S305509. eCollection 2021.
Complications of Cardiovascular Events in Patients Hospitalized with Influenza-Related Pneumonia
Liang Chen[SUP] 1 [/SUP], Xiudi Han[SUP] 2 [/SUP], YanLi Li[SUP] 3 [/SUP], Chunxiao Zhang[SUP] 4 [/SUP], Xiqian Xing[SUP] 5 [/SUP]
Affiliations
- PMID: 33859482
- PMCID: PMC8043795
- DOI: 10.2147/IDR.S305509
Abstract
Purpose: Influenza virus infections are a key cause of community-acquired pneumonia (CAP). Cardiovascular events (CVEs) are common among CAP and influenza patients, but there have been few population-based studies of influenza-related pneumonia (Flu-p) patients published to date.
Methods: A retrospective analysis of 1191 immunocompetent hospitalized adult Flu-p patients from January 2012 to December 2018 in five teaching hospitals in China was conducted.
Results: A total of 24.6% (293/1191) of patients developed at least one form of CVE-related complication while hospitalized. In a multivariate logistic regression analysis, hypertension, cerebrovascular disease, coronary artery disease, preexisting heart failure, systolic blood pressure <90 mmHg, respiratory rates ?30 breaths/min, a lymphocyte count <0.8?10[SUP]9[/SUP]/L, PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] <300 mmHg, and systemic corticosteroid administration were independently associated with the incidence of CVEs; while early neuraminidase inhibitor treatment and angiotensin converting enzyme inhibitors/angiotensin II receptor blocker treatment were associated with a lower risk of CVEs. After controlling for potential confounding variables, we determined that CVEs were linked to a higher risk of 30-day mortality (OR 3.307, 95% CI 2.198-4.975, p < 0.001) in Flu-p patients.
Conclusion: CVE-related complications are common among hospitalized Flu-p patients and are associated with negative patient outcomes. Clarifying these CVE-related risk factors can aid in their clinical prevention and management.
Keywords: cardiovascular event; clinical outcome; influenza-related pneumonia; risk factor.