tetano
Editor, Senior Moderator
Infect Dis Rep
. 2025 Jul 7;17(4):79.
doi: 10.3390/idr17040079. The Role of Kidney Function in Predicting COVID-19 Severity and Clinical Outcomes: A Retrospective Analysis
Victor Muniz de Freitas[SUP] 1 [/SUP], Érika Bevilaqua Rangel[SUP] 1 2 [/SUP]
Affiliations
Background: Coronavirus disease 2019 (COVID-19) involves a complex interplay of dysregulated immune responses, a pro-inflammatory cytokine storm, endothelial injury, and thrombotic complications. This study aimed to evaluate the impact of kidney function on clinical, laboratory, and outcome parameters in patients hospitalized with COVID-19. Methods: We conducted a retrospective analysis of 359 patients admitted during the first wave of COVID-19, stratified by estimated glomerular filtration rate (eGFR < 60 vs. ≥60 mL/min/1.73 m[SUP]2[/SUP]). Data on demographics, vital signs, laboratory values, and clinical outcomes-including mortality, hemodialysis requirement, intensive care unit (ICU) admission, and mechanical ventilation (MV)-were collected. Univariate and multivariate linear regression, as well as area under the receiver operating characteristic curve (AUC-ROC) analyses, were performed. A p-value < 0.05 was considered statistically significant. Results: Patients with an eGFR < 60 were older and more likely to have systemic hypertension, chronic kidney disease, a history of solid organ transplantation, and immunosuppressive therapy. This group showed higher rates of mortality (41.6% vs. 19.2%), hemodialysis requirement (32.3% vs. 9.6%), ICU admission (50.9% vs. 37.9%), and MV (39.8% vs. 21.2%). Laboratory results revealed acidosis, anemia, lymphopenia, elevated inflammatory markers, and hyperkalemia. Conclusions: An admission eGFR < 60 mL/min/1.73 m[SUP]2[/SUP] is associated with worse clinical outcomes in COVID-19 and may serve as a simple, early marker for risk stratification.
Keywords: COVID-19; eGFR; laboratory parameters; outcomes; vital signs.
. 2025 Jul 7;17(4):79.
doi: 10.3390/idr17040079. The Role of Kidney Function in Predicting COVID-19 Severity and Clinical Outcomes: A Retrospective Analysis
Victor Muniz de Freitas[SUP] 1 [/SUP], Érika Bevilaqua Rangel[SUP] 1 2 [/SUP]
Affiliations
- PMID: 40700325
- DOI: 10.3390/idr17040079
Background: Coronavirus disease 2019 (COVID-19) involves a complex interplay of dysregulated immune responses, a pro-inflammatory cytokine storm, endothelial injury, and thrombotic complications. This study aimed to evaluate the impact of kidney function on clinical, laboratory, and outcome parameters in patients hospitalized with COVID-19. Methods: We conducted a retrospective analysis of 359 patients admitted during the first wave of COVID-19, stratified by estimated glomerular filtration rate (eGFR < 60 vs. ≥60 mL/min/1.73 m[SUP]2[/SUP]). Data on demographics, vital signs, laboratory values, and clinical outcomes-including mortality, hemodialysis requirement, intensive care unit (ICU) admission, and mechanical ventilation (MV)-were collected. Univariate and multivariate linear regression, as well as area under the receiver operating characteristic curve (AUC-ROC) analyses, were performed. A p-value < 0.05 was considered statistically significant. Results: Patients with an eGFR < 60 were older and more likely to have systemic hypertension, chronic kidney disease, a history of solid organ transplantation, and immunosuppressive therapy. This group showed higher rates of mortality (41.6% vs. 19.2%), hemodialysis requirement (32.3% vs. 9.6%), ICU admission (50.9% vs. 37.9%), and MV (39.8% vs. 21.2%). Laboratory results revealed acidosis, anemia, lymphopenia, elevated inflammatory markers, and hyperkalemia. Conclusions: An admission eGFR < 60 mL/min/1.73 m[SUP]2[/SUP] is associated with worse clinical outcomes in COVID-19 and may serve as a simple, early marker for risk stratification.
Keywords: COVID-19; eGFR; laboratory parameters; outcomes; vital signs.