tetano
Editor, Senior Moderator
Infect Chemother
. 2021 Mar;53(1):1-12.
doi: 10.3947/ic.2020.0109.
Effectiveness of Mavrilimumab in Viral Infections Including SARS-CoV-2 Infection - A Brief Review
Kinal Bhatt[SUP] 1 [/SUP], Radhika Garimella[SUP] 2 [/SUP], Rahima Taugir[SUP] 3 [/SUP], Isha Mehta[SUP] 4 [/SUP], Muhammad Jamal[SUP] 5 [/SUP], Rupalakshmi Vijayan[SUP] 6 [/SUP], Rita Offor[SUP] 7 [/SUP], Kanayo Nwankwo[SUP] 8 [/SUP], Uroosa Arif[SUP] 9 [/SUP], Khurram Waheed[SUP] 10 [/SUP], Priyanka Kumari[SUP] 11 [/SUP], Maulik Lathiya[SUP] 12 [/SUP], George Michel[SUP] 13 [/SUP], Naushira Pandya[SUP] 14 [/SUP], John Halpern[SUP] 14 [/SUP], Hassan Nasir[SUP] 14 [/SUP], Marcos A Sanchez-Gonzalez[SUP] 15 [/SUP]
Affiliations
Abstract
Hyperinflammation and cytokine storm has been noted as a poor prognostic factor in patients with severe pneumonia related to coronavirus disease 2019 (COVID-19). In COVID-19, pathogenic myeloid cell overactivation is found to be a vital mediator of damage to tissues, hypercoagulability, and the cytokine storm. These cytokines unselectively infiltrate various tissues, such as the lungs and heart, and nervous system. This cytokine storm can hence cause multi-organ dysfunction and life-threatening complications. Mavrilimumab is a monoclonal antibody (mAb) that may be helpful in some cases with COVID-19. During an inflammation, Granulocyte-macrophage colony-stimulating factor (GM-CSF) release is crucial to driving both innate and adaptive immune responses. The GM-CSF immune response is triggered when an antigen attaches to the host cell and induces the signaling pathway. Mavrilimumab antagonizes the action of GM-CSF and decreases the hyperinflammation associated with pneumonia in COVID-19, therefore strengthening the rationale that mavrilimumab when added to the standard protocol of treatment could improve the clinical outcomes in COVID-19 patients, specifically those patients with pneumonia. With this review paper, we aim to demonstrate the inhibitory effect of mavrilimumab on cytokine storms in patients with COVID-19 by reviewing published clinical trials and emphasize the importance of extensive future trials.
Keywords: COVID-19; Cytokine storm; Mavrilimumab; Monoclonal antibody; SARS-CoV2.
. 2021 Mar;53(1):1-12.
doi: 10.3947/ic.2020.0109.
Effectiveness of Mavrilimumab in Viral Infections Including SARS-CoV-2 Infection - A Brief Review
Kinal Bhatt[SUP] 1 [/SUP], Radhika Garimella[SUP] 2 [/SUP], Rahima Taugir[SUP] 3 [/SUP], Isha Mehta[SUP] 4 [/SUP], Muhammad Jamal[SUP] 5 [/SUP], Rupalakshmi Vijayan[SUP] 6 [/SUP], Rita Offor[SUP] 7 [/SUP], Kanayo Nwankwo[SUP] 8 [/SUP], Uroosa Arif[SUP] 9 [/SUP], Khurram Waheed[SUP] 10 [/SUP], Priyanka Kumari[SUP] 11 [/SUP], Maulik Lathiya[SUP] 12 [/SUP], George Michel[SUP] 13 [/SUP], Naushira Pandya[SUP] 14 [/SUP], John Halpern[SUP] 14 [/SUP], Hassan Nasir[SUP] 14 [/SUP], Marcos A Sanchez-Gonzalez[SUP] 15 [/SUP]
Affiliations
- PMID: 34409778
- DOI: 10.3947/ic.2020.0109
Abstract
Hyperinflammation and cytokine storm has been noted as a poor prognostic factor in patients with severe pneumonia related to coronavirus disease 2019 (COVID-19). In COVID-19, pathogenic myeloid cell overactivation is found to be a vital mediator of damage to tissues, hypercoagulability, and the cytokine storm. These cytokines unselectively infiltrate various tissues, such as the lungs and heart, and nervous system. This cytokine storm can hence cause multi-organ dysfunction and life-threatening complications. Mavrilimumab is a monoclonal antibody (mAb) that may be helpful in some cases with COVID-19. During an inflammation, Granulocyte-macrophage colony-stimulating factor (GM-CSF) release is crucial to driving both innate and adaptive immune responses. The GM-CSF immune response is triggered when an antigen attaches to the host cell and induces the signaling pathway. Mavrilimumab antagonizes the action of GM-CSF and decreases the hyperinflammation associated with pneumonia in COVID-19, therefore strengthening the rationale that mavrilimumab when added to the standard protocol of treatment could improve the clinical outcomes in COVID-19 patients, specifically those patients with pneumonia. With this review paper, we aim to demonstrate the inhibitory effect of mavrilimumab on cytokine storms in patients with COVID-19 by reviewing published clinical trials and emphasize the importance of extensive future trials.
Keywords: COVID-19; Cytokine storm; Mavrilimumab; Monoclonal antibody; SARS-CoV2.