tetano
Editor, Senior Moderator
J Infect Dis. 2019 May 6. pii: jiz212. doi: 10.1093/infdis/jiz212. [Epub ahead of print]
[h=1]Infant pneumococcal carriage during influenza, RSV and hMPV respiratory illness within a maternal influenza immunization trial.[/h] Murray AF[SUP]1[/SUP], Englund JA[SUP]2[/SUP], Kuypers J[SUP]3[/SUP], Tielsch JM[SUP]4[/SUP], Katz J[SUP]5[/SUP], Khatry SK[SUP]6[/SUP], Leclerq SC[SUP]6[/SUP], Chu HY[SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] In this post-hoc analysis of nasopharyngeal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, RSV or hMPV illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these three viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to infants born to placebo mothers (58.1% versus 71.6%, p=0.03). No difference was observed in RSV- or hMPV-infected infants (p=0.94, 0.11). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection.
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
[h=4]KEYWORDS:[/h] RSV; hMPV; influenza; maternal immunization; pneumococcus; vaccine
PMID: 31056697 DOI: 10.1093/infdis/jiz212
[h=1]Infant pneumococcal carriage during influenza, RSV and hMPV respiratory illness within a maternal influenza immunization trial.[/h] Murray AF[SUP]1[/SUP], Englund JA[SUP]2[/SUP], Kuypers J[SUP]3[/SUP], Tielsch JM[SUP]4[/SUP], Katz J[SUP]5[/SUP], Khatry SK[SUP]6[/SUP], Leclerq SC[SUP]6[/SUP], Chu HY[SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] In this post-hoc analysis of nasopharyngeal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, RSV or hMPV illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these three viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to infants born to placebo mothers (58.1% versus 71.6%, p=0.03). No difference was observed in RSV- or hMPV-infected infants (p=0.94, 0.11). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection.
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
[h=4]KEYWORDS:[/h] RSV; hMPV; influenza; maternal immunization; pneumococcus; vaccine
PMID: 31056697 DOI: 10.1093/infdis/jiz212