gsgs
Registered User
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On a different but related note, a few days ago we posted on an interview given by Dr. Andrew Jeremijenko in Australia. There he said the Indonesian virus isolated from birds differed from that isolated from humans and the closest match to the human version came from a kitten he swabbed. I have since had some communication with Dr. Jeremijenko and he clarified the difference in the bird and human viruses lay in a single amino acid in the polybasic cleavage site. This kind of difference would not be expected to affect pathogenicity or host specificity, but it is striking that almost all the human isolates have one version and almost all the avian isolates the other. The cat has the human version, suggesting it is related to, or a marker for, mammalian host adaptation
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On a different but related note, a few days ago we posted on an interview given by Dr. Andrew Jeremijenko in Australia. There he said the Indonesian virus isolated from birds differed from that isolated from humans and the closest match to the human version came from a kitten he swabbed. I have since had some communication with Dr. Jeremijenko and he clarified the difference in the bird and human viruses lay in a single amino acid in the polybasic cleavage site. This kind of difference would not be expected to affect pathogenicity or host specificity, but it is striking that almost all the human isolates have one version and almost all the avian isolates the other. The cat has the human version, suggesting it is related to, or a marker for, mammalian host adaptation
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