Ronan Kelly
Retired 2020
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Increasing ventilator surge capacity in disasters: Ventilation of four adult-human-sized sheep on a single ventilator with a modified circuit
References and further reading may be available for this article. To view references and further reading you must purchase this article.
Lorenzo Paladinoa, , , Mark Silverberga, Jean G. Charchafliehb, Julie K. Easonc, Brian J. Wrighta, Nicholas Palamidessia, Bonnie Arquillaa, Richard Sinerta and Seth Manoacha
aDepartment of Emergency Medicine, State University of New York Downstate Medical Center, United States
bDepartment of Anesthesiology, State University of New York Downstate Medical Center, United States
cDepartment of Respiratory Therapy, State University of New York Downstate Medical Center, United States
Received 11 September 2007; accepted 4 October 2007. Available online 31 December 2007.
Summary
Objective
Recent manmade and natural disasters have focused attention on the need to provide care to large groups of patients. Clinicians, ethicists, and public health officials have been particularly concerned about mechanical ventilator surge capacity and have suggested stockpiling ventilators, rationing, and providing manual ventilation. These possible solutions are complex and variously limited by legal, monetary, physical, and human capital restraints. We conducted a study to determine if a single mechanical ventilator can adequately ventilate four adult-human-sized sheep for 12 h.
Methods
We utilized a four-limbed ventilator circuit connected in parallel. Four 70-kg sheep were intubated, sedated, administered neuromuscular blockade and placed on a single ventilator for 12 h. The initial ventilator settings were: synchronized intermittent mandatory ventilation with 100% oxygen at 16 breaths/min and tidal volume of 6 ml/kg combined sheep weight. Arterial blood gas, heart rate, and mean arterial pressure measurements were obtained from all four sheep at time zero and at pre-determined times over the course of 12 h.
Results
The ventilator and modified circuit successfully oxygenated and ventilated the four sheep for 12 h. All sheep remained hemodynamically stable.
Conclusion
It is possible to ventilate four adult-human-sized sheep on a single ventilator for at least 12 h. This technique has the potential to improve disaster preparedness by expanding local ventilator surge capacity until emergency supplies can be delivered from central stockpiles. Further research should be conducted on ventilating individuals with different lung compliances and on potential microbial cross-contamination.
http://www.sciencedirect.com/scienc...serid=10&md5=ff811fa7db0461b660ca58f6c6f20e7b
Increasing ventilator surge capacity in disasters: Ventilation of four adult-human-sized sheep on a single ventilator with a modified circuit
References and further reading may be available for this article. To view references and further reading you must purchase this article.
Lorenzo Paladinoa, , , Mark Silverberga, Jean G. Charchafliehb, Julie K. Easonc, Brian J. Wrighta, Nicholas Palamidessia, Bonnie Arquillaa, Richard Sinerta and Seth Manoacha
aDepartment of Emergency Medicine, State University of New York Downstate Medical Center, United States
bDepartment of Anesthesiology, State University of New York Downstate Medical Center, United States
cDepartment of Respiratory Therapy, State University of New York Downstate Medical Center, United States
Received 11 September 2007; accepted 4 October 2007. Available online 31 December 2007.
Summary
Objective
Recent manmade and natural disasters have focused attention on the need to provide care to large groups of patients. Clinicians, ethicists, and public health officials have been particularly concerned about mechanical ventilator surge capacity and have suggested stockpiling ventilators, rationing, and providing manual ventilation. These possible solutions are complex and variously limited by legal, monetary, physical, and human capital restraints. We conducted a study to determine if a single mechanical ventilator can adequately ventilate four adult-human-sized sheep for 12 h.
Methods
We utilized a four-limbed ventilator circuit connected in parallel. Four 70-kg sheep were intubated, sedated, administered neuromuscular blockade and placed on a single ventilator for 12 h. The initial ventilator settings were: synchronized intermittent mandatory ventilation with 100% oxygen at 16 breaths/min and tidal volume of 6 ml/kg combined sheep weight. Arterial blood gas, heart rate, and mean arterial pressure measurements were obtained from all four sheep at time zero and at pre-determined times over the course of 12 h.
Results
The ventilator and modified circuit successfully oxygenated and ventilated the four sheep for 12 h. All sheep remained hemodynamically stable.
Conclusion
It is possible to ventilate four adult-human-sized sheep on a single ventilator for at least 12 h. This technique has the potential to improve disaster preparedness by expanding local ventilator surge capacity until emergency supplies can be delivered from central stockpiles. Further research should be conducted on ventilating individuals with different lung compliances and on potential microbial cross-contamination.
http://www.sciencedirect.com/scienc...serid=10&md5=ff811fa7db0461b660ca58f6c6f20e7b
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