tetano
Editor, Senior Moderator
Am J Respir Crit Care Med. 2012 Feb 23. [Epub ahead of print]
Increased H1N1 Infection Rate in Children with Asthma.
Kloepfer KM, Olenec JP, Lee WM, Liu G, Vrtis RF, Roberg KA, Evans MD, Gangnon RE, Lemanske RF Jr, Gern JE.
Source
Medicine and Pediatrics, University of Wisconsin - Madison, Madison, Wisconsin, United States.
Abstract
RATIONALE:
2009 H1N1 Flu appeared to cause more severe cold symptoms during the 2009-2010 flu season.
OBJECTIVES:
We evaluated H1N1 infections during peak viral season in children with and without asthma to determine if H1N1 infectivity rate and illness severity were greater in asthmatics.
METHODS:
180 children ages 4-12 years provided eight consecutive weekly nasal mucus samples from September 5 through October 24, 2009, and scored cold and asthma symptoms daily. Viral diagnostics were performed for all nasal samples.
MEASUREMENTS AND MAIN RESULTS:
161 children (95 asthmatic, 66 non-asthmatic) completed at least 6 of the 8 nasal samples. The incidence of H1N1 infection was significantly higher in asthmatics (41%) than in non-asthmatics (24%, OR, 4; 95% CI 1.8-9; p < 0.001), but rates of human rhinovirus (HRV; 90% each) and other viral infections (47% vs. 41%) were similar. In children with asthma, there was a nonsignificant trend for increased loss of asthma control during H1N1 infections compared to HRV infections (38% vs. 21%; OR=2.6, 95% CI 0.9-7.2, p=0.07).
CONCLUSION:
During peak 2009 H1N1 Flu season, asthmatic children were infected almost twice as often with H1N1 compared to other respiratory viruses. H1N1 infection also caused increased severity of cold symptoms compared to other viral infections. Given the increased susceptibility for infection in asthmatics, these findings reinforce the need for yearly influenza vaccination to prevent infection, and raise new questions about the mechanism for enhanced susceptibility to influenza infection in asthma. Abstract: 239 words Keywords: asthma, viral infection, influenza.
PMID:
22366048
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22366048
Increased H1N1 Infection Rate in Children with Asthma.
Kloepfer KM, Olenec JP, Lee WM, Liu G, Vrtis RF, Roberg KA, Evans MD, Gangnon RE, Lemanske RF Jr, Gern JE.
Source
Medicine and Pediatrics, University of Wisconsin - Madison, Madison, Wisconsin, United States.
Abstract
RATIONALE:
2009 H1N1 Flu appeared to cause more severe cold symptoms during the 2009-2010 flu season.
OBJECTIVES:
We evaluated H1N1 infections during peak viral season in children with and without asthma to determine if H1N1 infectivity rate and illness severity were greater in asthmatics.
METHODS:
180 children ages 4-12 years provided eight consecutive weekly nasal mucus samples from September 5 through October 24, 2009, and scored cold and asthma symptoms daily. Viral diagnostics were performed for all nasal samples.
MEASUREMENTS AND MAIN RESULTS:
161 children (95 asthmatic, 66 non-asthmatic) completed at least 6 of the 8 nasal samples. The incidence of H1N1 infection was significantly higher in asthmatics (41%) than in non-asthmatics (24%, OR, 4; 95% CI 1.8-9; p < 0.001), but rates of human rhinovirus (HRV; 90% each) and other viral infections (47% vs. 41%) were similar. In children with asthma, there was a nonsignificant trend for increased loss of asthma control during H1N1 infections compared to HRV infections (38% vs. 21%; OR=2.6, 95% CI 0.9-7.2, p=0.07).
CONCLUSION:
During peak 2009 H1N1 Flu season, asthmatic children were infected almost twice as often with H1N1 compared to other respiratory viruses. H1N1 infection also caused increased severity of cold symptoms compared to other viral infections. Given the increased susceptibility for infection in asthmatics, these findings reinforce the need for yearly influenza vaccination to prevent infection, and raise new questions about the mechanism for enhanced susceptibility to influenza infection in asthma. Abstract: 239 words Keywords: asthma, viral infection, influenza.
PMID:
22366048
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22366048