tetano
Editor, Senior Moderator
Immunol Rev
. 2022 Jun 30.
doi: 10.1111/imr.13114. Online ahead of print.
The nervous system during COVID-19: Caught in the crossfire
Nick R Natale[SUP] 1 2 3 4 [/SUP], John R Lukens[SUP] 2 3 4 5 [/SUP], William A Petri Jr[SUP] 1 2 3 4 5 6 7 [/SUP]
Affiliations
Abstract
SARS-CoV-2, the virus that causes coronavirus disease (COVID)-19, has become a persistent global health threat. Individuals who are symptomatic for COVID-19 frequently exhibit respiratory illness, which is often accompanied by neurological symptoms of anosmia and fatigue. Mounting clinical data also indicate that many COVID-19 patients display long-term neurological disorders postinfection such as cognitive decline, which emphasizes the need to further elucidate the effects of COVID-19 on the central nervous system. In this review article, we summarize an emerging body of literature describing the impact of SARS-CoV-2 infection on central nervous system (CNS) health and highlight important areas of future investigation.
Keywords: COVID-19; NeuroCOVID; SARS-CoV-2; anosmia; neuroimmunology; neuroinflammation; olfactory system.
. 2022 Jun 30.
doi: 10.1111/imr.13114. Online ahead of print.
The nervous system during COVID-19: Caught in the crossfire
Nick R Natale[SUP] 1 2 3 4 [/SUP], John R Lukens[SUP] 2 3 4 5 [/SUP], William A Petri Jr[SUP] 1 2 3 4 5 6 7 [/SUP]
Affiliations
- PMID: 35770683
- DOI: 10.1111/imr.13114
Abstract
SARS-CoV-2, the virus that causes coronavirus disease (COVID)-19, has become a persistent global health threat. Individuals who are symptomatic for COVID-19 frequently exhibit respiratory illness, which is often accompanied by neurological symptoms of anosmia and fatigue. Mounting clinical data also indicate that many COVID-19 patients display long-term neurological disorders postinfection such as cognitive decline, which emphasizes the need to further elucidate the effects of COVID-19 on the central nervous system. In this review article, we summarize an emerging body of literature describing the impact of SARS-CoV-2 infection on central nervous system (CNS) health and highlight important areas of future investigation.
Keywords: COVID-19; NeuroCOVID; SARS-CoV-2; anosmia; neuroimmunology; neuroinflammation; olfactory system.