tetano
Editor, Senior Moderator
Obes Res Clin Pract. 2019 Sep 18. pii: S1871-403X(18)30632-X. doi: 10.1016/j.orcp.2019.05.003. [Epub ahead of print]
[h=1]Immunity to influenza: Impact of obesity.[/h] Rojas-Osornio SA[SUP]1[/SUP], Cruz-Hern?ndez TR[SUP]1[/SUP], Drago-Serrano ME[SUP]2[/SUP], Campos-Rodr?guez R[SUP]3[/SUP].
[h=3]Author information[/h] 1 Secci?n de Estudios de Posgrado e Investigaci?n, Escuela Superior de Medicina, Instituto Polit?cnico Nacional, Plan de San Luis y D?az Mir?n s/n, CP 11340, CDMX, Mexico. 2 Departamento de Sistemas Biol?gicos, Universidad Aut?noma Metropolitana, Unidad Xochimilco. Calzada del Hueso No. 1100, CP 04960, CDMX, Mexico. 3 Secci?n de Estudios de Posgrado e Investigaci?n, Escuela Superior de Medicina, Instituto Polit?cnico Nacional, Plan de San Luis y D?az Mir?n s/n, CP 11340, CDMX, Mexico. Electronic address: sandii38@yahoo.com.mx.
[h=3]Abstract[/h] Obesity is a health concern that is recognized as a critical factor for vulnerability to influenza A/pdmH1N1 virus infection, with epidemiological and clinical impacts. In humans, obesity induces disturbances in inflammatory and immune responses to the influenza virus and in some cases, this leads to severe complications, with fatal outcomes. Obesity impairs immunity by altering the response of cytokines, resulting in a decrease in the cytotoxic cell response of immunocompetent cells which have a key anti-viral role. Additionally, obesity seems to disturb the balance of endocrine hormones, such as leptin, that affect the interplay between metabolic and immune systems. This contribution focuses on reviewing the current epidemiologic data for the immune response to immunity in obese humans and animal models. In doing so, we aim to provide potential mechanisms to enhance immunity to influenza A/pdmH1N1 virus infection and protective factors in obese people.
Copyright ? 2019. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Influenza A/pdmH1N1 virus; Leptin; Obesity; Vaccine
PMID: 31542241 DOI: 10.1016/j.orcp.2019.05.003
[h=1]Immunity to influenza: Impact of obesity.[/h] Rojas-Osornio SA[SUP]1[/SUP], Cruz-Hern?ndez TR[SUP]1[/SUP], Drago-Serrano ME[SUP]2[/SUP], Campos-Rodr?guez R[SUP]3[/SUP].
[h=3]Author information[/h] 1 Secci?n de Estudios de Posgrado e Investigaci?n, Escuela Superior de Medicina, Instituto Polit?cnico Nacional, Plan de San Luis y D?az Mir?n s/n, CP 11340, CDMX, Mexico. 2 Departamento de Sistemas Biol?gicos, Universidad Aut?noma Metropolitana, Unidad Xochimilco. Calzada del Hueso No. 1100, CP 04960, CDMX, Mexico. 3 Secci?n de Estudios de Posgrado e Investigaci?n, Escuela Superior de Medicina, Instituto Polit?cnico Nacional, Plan de San Luis y D?az Mir?n s/n, CP 11340, CDMX, Mexico. Electronic address: sandii38@yahoo.com.mx.
[h=3]Abstract[/h] Obesity is a health concern that is recognized as a critical factor for vulnerability to influenza A/pdmH1N1 virus infection, with epidemiological and clinical impacts. In humans, obesity induces disturbances in inflammatory and immune responses to the influenza virus and in some cases, this leads to severe complications, with fatal outcomes. Obesity impairs immunity by altering the response of cytokines, resulting in a decrease in the cytotoxic cell response of immunocompetent cells which have a key anti-viral role. Additionally, obesity seems to disturb the balance of endocrine hormones, such as leptin, that affect the interplay between metabolic and immune systems. This contribution focuses on reviewing the current epidemiologic data for the immune response to immunity in obese humans and animal models. In doing so, we aim to provide potential mechanisms to enhance immunity to influenza A/pdmH1N1 virus infection and protective factors in obese people.
Copyright ? 2019. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Influenza A/pdmH1N1 virus; Leptin; Obesity; Vaccine
PMID: 31542241 DOI: 10.1016/j.orcp.2019.05.003