Giuseppe
Emeritus
[Source: Immunity and Ageing, full text: (LINK). Abstract, edited.]
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Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
Sijia Chen, Anton JM de Craen, Yotam Raz, Evelyna Derhovanessian, Ann CTM Vossen, Westendorp GJ Rudi, Graham Pawelec and Andrea B Maier
Immunity & Ageing 2012, 9:18 doi:10.1186/1742-4933-9-18, Published: 28 August 2012
Abstract (provisional)
Background
Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old.
Results
CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05).
Conclusions
In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.
-Sijia Chen, Anton JM de Craen, Yotam Raz, Evelyna Derhovanessian, Ann CTM Vossen, Westendorp GJ Rudi, Graham Pawelec and Andrea B Maier
Immunity & Ageing 2012, 9:18 doi:10.1186/1742-4933-9-18, Published: 28 August 2012
Abstract (provisional)
Background
Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old.
Results
CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05).
Conclusions
In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.
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