tetano
Editor, Senior Moderator
J Infect Dev Ctries. 2014 Jan 15;8(1):101-9. doi: 10.3855/jidc.3147.
Immune response to influenza A(H1N1)v in HIV-infected patients.
Sansonetti P, Sali M, Fabbiani M, Morandi M, Martucci R, Danesh A, Delogu G, Bermejo-Martin J, Sanguinetti M, Kelvin D, Cauda R, Fadda G, Rubino S.
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Abstract
INTRODUCTION:
HIV infection is considered a risk factor for severe outcomes of influenza A(H1N1)v infection. However, data on immune response against influenza A(H1N1)v virus in HIV-infected patients are lacking.
METHODOLOGY:
Data from seven HIV-positive and 14 HIV-negative patients infected with A(H1N1)v and from 23 HIV-positive and six HIV-negative asymptomatic controls were analyzed to evaluate the clinical picture, A(H1N1)v viral shedding, and the immune response against the virus.
RESULTS:
Patients displayed mainly upper respiratory tract diseases (57.1%), while pneumonia was diagnosed only in HIV-negative patients (23.8% of subjects, of which 4.8% required intensive care unit admission). At day seven, 29% of HIV-infected patients were still positive for A(H1N1)v by RT-PCR on nasopharyngeal swabs. Interestingly, a persistence of CXCL10 secretion at high level and lower IL-6 levels was observed in HIV-positive subjects. The geometric mean haemagglutination inhibition titer (HI-GMT) and anti-influenza IgM levels were lower in HIV-positive individuals while anti-influenza IgG levels remained similar in the two groups.
CONCLUSIONS:
The immune impairment due to HIV infection could affect A(H1N1)v clearance and could lead to a lower antibody response and a persistent secretion of CXCL10 at high levels. However, the lower IL-6 secretion and treatment with highly active antiretroviral therapy (HAART) could result in a milder clinical picture.
PMID:
24423719
[PubMed - in process]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/24423719
Immune response to influenza A(H1N1)v in HIV-infected patients.
Sansonetti P, Sali M, Fabbiani M, Morandi M, Martucci R, Danesh A, Delogu G, Bermejo-Martin J, Sanguinetti M, Kelvin D, Cauda R, Fadda G, Rubino S.
Author information
Abstract
INTRODUCTION:
HIV infection is considered a risk factor for severe outcomes of influenza A(H1N1)v infection. However, data on immune response against influenza A(H1N1)v virus in HIV-infected patients are lacking.
METHODOLOGY:
Data from seven HIV-positive and 14 HIV-negative patients infected with A(H1N1)v and from 23 HIV-positive and six HIV-negative asymptomatic controls were analyzed to evaluate the clinical picture, A(H1N1)v viral shedding, and the immune response against the virus.
RESULTS:
Patients displayed mainly upper respiratory tract diseases (57.1%), while pneumonia was diagnosed only in HIV-negative patients (23.8% of subjects, of which 4.8% required intensive care unit admission). At day seven, 29% of HIV-infected patients were still positive for A(H1N1)v by RT-PCR on nasopharyngeal swabs. Interestingly, a persistence of CXCL10 secretion at high level and lower IL-6 levels was observed in HIV-positive subjects. The geometric mean haemagglutination inhibition titer (HI-GMT) and anti-influenza IgM levels were lower in HIV-positive individuals while anti-influenza IgG levels remained similar in the two groups.
CONCLUSIONS:
The immune impairment due to HIV infection could affect A(H1N1)v clearance and could lead to a lower antibody response and a persistent secretion of CXCL10 at high levels. However, the lower IL-6 secretion and treatment with highly active antiretroviral therapy (HAART) could result in a milder clinical picture.
PMID:
24423719
[PubMed - in process]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/24423719