tetano
Editor, Senior Moderator
Immune Netw
. 2021 Oct 11;21(5):e32.
doi: 10.4110/in.2021.21.e32. eCollection 2021 Oct.
SARS-CoV-2 Delta (B.1.617.2) Variant: A Unique T478K Mutation in Receptor Binding Motif (RBM) of Spike Gene
Hyunjhung Jhun[SUP] 1 [/SUP], Ho-Young Park[SUP] 2 [/SUP], Yasmin Hisham[SUP] 3 [/SUP], Chang-Seon Song[SUP] 4 [/SUP], Soohyun Kim[SUP] 3 4 [/SUP]
Affiliations
Abstract
Over two hundred twenty-eight million cases of coronavirus disease 2019 (COVID-19) in the world have been reported until the 21[SUP]st[/SUP] of September 2021 after the first rise in December 2019. The virus caused the disease called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 4 million deaths blame COVID-19 during the last one year and 8 months in the world. Currently, four SARS-CoV-2 variants of concern are mainly focused by pandemic studies with limited experiments to translate the infectivity and pathogenicity of each variant. The SARS-CoV-2 α, β, γ, and δ variant of concern was originated from United Kingdom, South Africa, Brazil/Japan, and India, respectively. The classification of SARS-CoV-2 variant is based on the mutation in spike (S) gene on the envelop of SARS-CoV-2. This review describes four SARS-CoV-2 α, β, γ, and δ variants of concern including SARS-CoV-2 ε, ζ, η, ι, κ, and B.1.617.3 variants of interest and alert. Recently, SARS-CoV-2 δ variant prevails over different countries that have 3 unique mutation sites: E156del/R158G in the N-terminal domain and T478K in a crucial receptor binding domain. A particular mutation in the functional domain of the S gene is probably associated with the infectivity and pathogenesis of the SARS-CoV-2 variant.
Keywords: COVID-19 delta; Receptor binding motif (RBM); SARS-CoV-2; Spike gene; T478K.
. 2021 Oct 11;21(5):e32.
doi: 10.4110/in.2021.21.e32. eCollection 2021 Oct.
SARS-CoV-2 Delta (B.1.617.2) Variant: A Unique T478K Mutation in Receptor Binding Motif (RBM) of Spike Gene
Hyunjhung Jhun[SUP] 1 [/SUP], Ho-Young Park[SUP] 2 [/SUP], Yasmin Hisham[SUP] 3 [/SUP], Chang-Seon Song[SUP] 4 [/SUP], Soohyun Kim[SUP] 3 4 [/SUP]
Affiliations
- PMID: 34796036
- PMCID: PMC8568914
- DOI: 10.4110/in.2021.21.e32
Abstract
Over two hundred twenty-eight million cases of coronavirus disease 2019 (COVID-19) in the world have been reported until the 21[SUP]st[/SUP] of September 2021 after the first rise in December 2019. The virus caused the disease called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 4 million deaths blame COVID-19 during the last one year and 8 months in the world. Currently, four SARS-CoV-2 variants of concern are mainly focused by pandemic studies with limited experiments to translate the infectivity and pathogenicity of each variant. The SARS-CoV-2 α, β, γ, and δ variant of concern was originated from United Kingdom, South Africa, Brazil/Japan, and India, respectively. The classification of SARS-CoV-2 variant is based on the mutation in spike (S) gene on the envelop of SARS-CoV-2. This review describes four SARS-CoV-2 α, β, γ, and δ variants of concern including SARS-CoV-2 ε, ζ, η, ι, κ, and B.1.617.3 variants of interest and alert. Recently, SARS-CoV-2 δ variant prevails over different countries that have 3 unique mutation sites: E156del/R158G in the N-terminal domain and T478K in a crucial receptor binding domain. A particular mutation in the functional domain of the S gene is probably associated with the infectivity and pathogenesis of the SARS-CoV-2 variant.
Keywords: COVID-19 delta; Receptor binding motif (RBM); SARS-CoV-2; Spike gene; T478K.