Mary Wilson
Well-known member
JANUARY 22 2024
Subject Area: Immunology and Allergy
https://doi.org/10.1159/000535736
Eva Untersmayr; Carina Venter; Peter Smith; Johanna Rohrhofer Cebile Ndwandwe; Jurgen Schwarze; Emer Shannon; Milena Sokolowska;
Corinna Sadlier; Liam O’Mahony
Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in a prolonged multisystem disorder termed long COVID, which may affect up to 10% of people following coronavirus disease 2019 (COVID-19). It is currently unclear why certain individuals do not fully recover following SARS-CoV-2 infection.
Summary: In this review, we examine immunological mechanisms that may underpin the pathophysiology of long COVID. These mechanisms include an inappropriate immune response to acute SARS-CoV-2 infection, immune cell exhaustion, immune cell metabolic reprogramming, a persistent SARS-CoV-2 reservoir, reactivation of other viruses, inflammatory responses impacting the central nervous system, autoimmunity, microbiome dysbiosis, and dietary factors.
Key Messages: Unfortunately, the currently available diagnostic and treatment options for long COVID are inadequate, and more clinical trials are needed that match experimental interventions to underlying immunological mechanisms.
https://karger.com/iaa/article/doi/...991/Immune-Mechanisms-Underpinning-Long-COVID
Subject Area: Immunology and Allergy
https://doi.org/10.1159/000535736
Eva Untersmayr; Carina Venter; Peter Smith; Johanna Rohrhofer Cebile Ndwandwe; Jurgen Schwarze; Emer Shannon; Milena Sokolowska;
Corinna Sadlier; Liam O’Mahony
Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in a prolonged multisystem disorder termed long COVID, which may affect up to 10% of people following coronavirus disease 2019 (COVID-19). It is currently unclear why certain individuals do not fully recover following SARS-CoV-2 infection.
Summary: In this review, we examine immunological mechanisms that may underpin the pathophysiology of long COVID. These mechanisms include an inappropriate immune response to acute SARS-CoV-2 infection, immune cell exhaustion, immune cell metabolic reprogramming, a persistent SARS-CoV-2 reservoir, reactivation of other viruses, inflammatory responses impacting the central nervous system, autoimmunity, microbiome dysbiosis, and dietary factors.
Key Messages: Unfortunately, the currently available diagnostic and treatment options for long COVID are inadequate, and more clinical trials are needed that match experimental interventions to underlying immunological mechanisms.
https://karger.com/iaa/article/doi/...991/Immune-Mechanisms-Underpinning-Long-COVID