tetano
Editor, Senior Moderator
Epidemiol Infect. 2015 Mar 17:1-10. [Epub ahead of print]
[h=1]IFITM3 rs12252 T>C polymorphism is associated with the risk of severe influenza: a meta-analysis.[/h] Xuan Y[SUP]1[/SUP], Wang LN[SUP]1[/SUP], Li W[SUP]2[/SUP], Zi HR[SUP]1[/SUP], Guo Y[SUP]1[/SUP], Yan WJ[SUP]1[/SUP], Chen XB[SUP]1[/SUP], Wei PM[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The interferon-inducible transmembrane protein 3 (IFITM3), as one of the key genes involved in the interferon pathway, is critical for defending the host against influenza virus, and the rs12252 T>C variant in IFITM3 might be associated with susceptibility to severe influenza. Owing to contradictory and inconclusive results, we performed a meta-analysis to assess the association between rs12252 T>C polymorphism and severe influenza risk. A comprehensive literature search up to 1 August 2014 was conducted in EMBASE, Pubmed, Web of Science, VIP, Wanfang and CNKI databases. Four eligible studies with a total of 445 influenza patients and 3396 controls were included in this meta-analysis. Overall, our results demonstrated a significant association between the IFITM3 rs12252 T>C polymorphism and influenza risk [C vs. T: odds ratio (OR) 1?68, 95% confidence interval (CI) 1?32-2?13; CC vs. CT+TT: OR 2?38, 95% CI 1?52-3?73; CC+CT vs. TT: OR 1?62, 95% CI 1?18-2?22]. Stratification by ethnicity indicated that the variant C allele was associated with an 88% increased risk of influenza in Asians (C vs. T: OR 1?88, 95% CI 1?34-2?62). Moreover, subjects carrying the variant C allele had an increased risk of developing severe illness upon influenza infection (C vs. T: OR 2?70, 95% CI 1?86-3?94). However, no significant association was observed in patients with mild infection (C vs. T: OR 1?26, 95% CI 0?93-1?71). Our meta-analysis suggests that IFITM3 rs12252 T>C polymorphism is significantly associated with increased risk of severe influenza but not with the chance of initial virus infection.
[h=4]KEYWORDS:[/h] polymorphism
PMID: 25778715 [PubMed - as supplied by publisher]
[h=1]IFITM3 rs12252 T>C polymorphism is associated with the risk of severe influenza: a meta-analysis.[/h] Xuan Y[SUP]1[/SUP], Wang LN[SUP]1[/SUP], Li W[SUP]2[/SUP], Zi HR[SUP]1[/SUP], Guo Y[SUP]1[/SUP], Yan WJ[SUP]1[/SUP], Chen XB[SUP]1[/SUP], Wei PM[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The interferon-inducible transmembrane protein 3 (IFITM3), as one of the key genes involved in the interferon pathway, is critical for defending the host against influenza virus, and the rs12252 T>C variant in IFITM3 might be associated with susceptibility to severe influenza. Owing to contradictory and inconclusive results, we performed a meta-analysis to assess the association between rs12252 T>C polymorphism and severe influenza risk. A comprehensive literature search up to 1 August 2014 was conducted in EMBASE, Pubmed, Web of Science, VIP, Wanfang and CNKI databases. Four eligible studies with a total of 445 influenza patients and 3396 controls were included in this meta-analysis. Overall, our results demonstrated a significant association between the IFITM3 rs12252 T>C polymorphism and influenza risk [C vs. T: odds ratio (OR) 1?68, 95% confidence interval (CI) 1?32-2?13; CC vs. CT+TT: OR 2?38, 95% CI 1?52-3?73; CC+CT vs. TT: OR 1?62, 95% CI 1?18-2?22]. Stratification by ethnicity indicated that the variant C allele was associated with an 88% increased risk of influenza in Asians (C vs. T: OR 1?88, 95% CI 1?34-2?62). Moreover, subjects carrying the variant C allele had an increased risk of developing severe illness upon influenza infection (C vs. T: OR 2?70, 95% CI 1?86-3?94). However, no significant association was observed in patients with mild infection (C vs. T: OR 1?26, 95% CI 0?93-1?71). Our meta-analysis suggests that IFITM3 rs12252 T>C polymorphism is significantly associated with increased risk of severe influenza but not with the chance of initial virus infection.
[h=4]KEYWORDS:[/h] polymorphism
PMID: 25778715 [PubMed - as supplied by publisher]