Emily
Editor, Senior Moderator
http://cid.oxfordjournals.org/content/51/7/777.abstract
Iatrogenic Transmission of Human T Cell Lymphotropic Virus Type 1 and Hepatitis C Virus through Parenteral Treatment and Chemoprophylaxis of Sleeping Sickness in Colonial Equatorial Africa
Clin Infect Dis. (2010) 51(7): 777-784 doi:10.1086/656232
Jacques P?pin,,
Annie-Claude Labb?,
Fleurie Mamadou-Yaya,
Pascal Mb?lesso,
Sylvestre Mbadinga?,
Sylvie Deslandes,
Marie-Claude Locas,
and Eric Frost
[snip]
Conclusions.
Treatment of trypanosomiasis before 1951 may have caused iatrogenic HCV transmission. Population-wide half-yearly intramuscular pentamidine for trypanosomiasis chemoprophylaxis in 1947?1953 may have caused iatrogenic HTLV-1 transmission. These and other interventions against tropical diseases could have iatrogenically transmitted SIVcpz, jump-starting the HIV-1 epidemic. The excess mortality among patients with trypanosomiasis treated before 1951 supports this hypothesis.
Iatrogenic Transmission of Human T Cell Lymphotropic Virus Type 1 and Hepatitis C Virus through Parenteral Treatment and Chemoprophylaxis of Sleeping Sickness in Colonial Equatorial Africa
Clin Infect Dis. (2010) 51(7): 777-784 doi:10.1086/656232
Jacques P?pin,,
Annie-Claude Labb?,
Fleurie Mamadou-Yaya,
Pascal Mb?lesso,
Sylvestre Mbadinga?,
Sylvie Deslandes,
Marie-Claude Locas,
and Eric Frost
[snip]
Conclusions.
Treatment of trypanosomiasis before 1951 may have caused iatrogenic HCV transmission. Population-wide half-yearly intramuscular pentamidine for trypanosomiasis chemoprophylaxis in 1947?1953 may have caused iatrogenic HTLV-1 transmission. These and other interventions against tropical diseases could have iatrogenically transmitted SIVcpz, jump-starting the HIV-1 epidemic. The excess mortality among patients with trypanosomiasis treated before 1951 supports this hypothesis.