tetano
Editor, Senior Moderator
J Infect Dis. 2015 Jan 12. pii: jiv018. [Epub ahead of print]
[h=1]Human influenza A virus-specific CD8+ T cell response is long-lived.[/h] van de Sandt CE[SUP]1[/SUP], Hillaire ML[SUP]1[/SUP], Geelhoed-Mieras MM[SUP]1[/SUP], Osterhaus AD[SUP]2[/SUP], Fouchier RA[SUP]1[/SUP], Rimmelzwaan GF[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8[SUP]+[/SUP] cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells (PBMCs) obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 25583167 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25583167
[h=1]Human influenza A virus-specific CD8+ T cell response is long-lived.[/h] van de Sandt CE[SUP]1[/SUP], Hillaire ML[SUP]1[/SUP], Geelhoed-Mieras MM[SUP]1[/SUP], Osterhaus AD[SUP]2[/SUP], Fouchier RA[SUP]1[/SUP], Rimmelzwaan GF[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8[SUP]+[/SUP] cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells (PBMCs) obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 25583167 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25583167