tetano
Editor, Senior Moderator
Hum Vaccin Immunother
. 2021 Aug 18;1-7.
doi: 10.1080/21645515.2021.1957647. Online ahead of print.
Protecting adults at risk of pneumococcal infection and influenza from exposure to SARS-CoV-2
Edwin David George McIntosh[SUP] 1 [/SUP], K Feemster[SUP] 2 [/SUP], J Rello[SUP] 3 [/SUP]
Affiliations
Abstract
There is a paucity of evidence linking pneumococcal infection and influenza with SARS-CoV-2 and COVID-19. There is circumstantial evidence of the possibility of an association between S. pneumoniae and SARS-CoV-2 such as the increased binding of S. pneumoniae to coronavirus-infected human airway epithelium, the frequent use of broad-spectrum antibiotics in the management of COVID-19 which could mask secondary bacterial infection, and the observation that pneumococcal vaccination is associated with decreased SARS-CoV-2 nasopharyngeal swab positivity. We performed a targeted literature review for the year 2020, using search terms S. pneumoniae, influenza, SARS-CoV-2, and found 25 relevant articles of a total of 291. Pneumococcal and influenza vaccinations have the potential to contribute toward efforts aimed at reducing the health burden of SARS-CoV-2, especially by reducing preventable admissions to hospital for pneumonia and the consequent risk of nosocomial SARS-CoV-2 transmission.
Keywords: COVID-19; SARS-CoV-2; Streptococcus pneumoniae; co-infection; influenza; nosocomial infection; secondary bacterial infection; vaccination.
. 2021 Aug 18;1-7.
doi: 10.1080/21645515.2021.1957647. Online ahead of print.
Protecting adults at risk of pneumococcal infection and influenza from exposure to SARS-CoV-2
Edwin David George McIntosh[SUP] 1 [/SUP], K Feemster[SUP] 2 [/SUP], J Rello[SUP] 3 [/SUP]
Affiliations
- PMID: 34406914
- DOI: 10.1080/21645515.2021.1957647
Abstract
There is a paucity of evidence linking pneumococcal infection and influenza with SARS-CoV-2 and COVID-19. There is circumstantial evidence of the possibility of an association between S. pneumoniae and SARS-CoV-2 such as the increased binding of S. pneumoniae to coronavirus-infected human airway epithelium, the frequent use of broad-spectrum antibiotics in the management of COVID-19 which could mask secondary bacterial infection, and the observation that pneumococcal vaccination is associated with decreased SARS-CoV-2 nasopharyngeal swab positivity. We performed a targeted literature review for the year 2020, using search terms S. pneumoniae, influenza, SARS-CoV-2, and found 25 relevant articles of a total of 291. Pneumococcal and influenza vaccinations have the potential to contribute toward efforts aimed at reducing the health burden of SARS-CoV-2, especially by reducing preventable admissions to hospital for pneumonia and the consequent risk of nosocomial SARS-CoV-2 transmission.
Keywords: COVID-19; SARS-CoV-2; Streptococcus pneumoniae; co-infection; influenza; nosocomial infection; secondary bacterial infection; vaccination.