tetano
Editor, Senior Moderator
Hum Vaccin Immunother
. 2025 Dec;21(1):2543167.
doi: 10.1080/21645515.2025.2543167. Epub 2025 Aug 12. Pandemic paradox: How the COVID-19 crisis transformed vaccine hesitancy into a two-edged sword
Esteban Ortiz-Prado[SUP] 1 [/SUP], Isaac A Suárez-Sangucho[SUP] 1 [/SUP], Jorge Vasconez-Gonzalez[SUP] 1 [/SUP], Pablo A Santillan-Roldán[SUP] 1 2 [/SUP], Melisa Villavicencio-Gomezjurado[SUP] 1 [/SUP], Camila Salazar-Santoliva[SUP] 1 [/SUP], Andrea Tello-De-la-Torre[SUP] 1 [/SUP], Juan S Izquierdo-Condoy[SUP] 1 [/SUP]
Affiliations
The rapid development of COVID-19 vaccines was a landmark achievement that saved millions of lives. However, this success also intensified vaccine hesitancy, as misinformation, evolving public health guidelines, and growing distrust in institutions fueled anti-vaccine sentiment. In this opinion piece, we explore the paradoxical legacy of the COVID-19 vaccination campaign - how a global scientific triumph simultaneously gave rise to an emboldened anti-vaccine movement. Drawing on international data, we highlight the association between baseline vaccine acceptance and subsequent booster uptake and interpret these trends through the lens of the Health Belief Model. We further examine the psychological, cultural, political, and structural drivers of hesitancy and outline key strategies to rebuild public trust. Addressing this crisis requires proactive, evidence-informed, and culturally sensitive approaches to safeguard the future of global immunization efforts.
Keywords: COVID-19; SARS-CoV-2; anti-vaccine movement; public health; vaccines.
. 2025 Dec;21(1):2543167.
doi: 10.1080/21645515.2025.2543167. Epub 2025 Aug 12. Pandemic paradox: How the COVID-19 crisis transformed vaccine hesitancy into a two-edged sword
Esteban Ortiz-Prado[SUP] 1 [/SUP], Isaac A Suárez-Sangucho[SUP] 1 [/SUP], Jorge Vasconez-Gonzalez[SUP] 1 [/SUP], Pablo A Santillan-Roldán[SUP] 1 2 [/SUP], Melisa Villavicencio-Gomezjurado[SUP] 1 [/SUP], Camila Salazar-Santoliva[SUP] 1 [/SUP], Andrea Tello-De-la-Torre[SUP] 1 [/SUP], Juan S Izquierdo-Condoy[SUP] 1 [/SUP]
Affiliations
- PMID: 40791124
- DOI: 10.1080/21645515.2025.2543167
The rapid development of COVID-19 vaccines was a landmark achievement that saved millions of lives. However, this success also intensified vaccine hesitancy, as misinformation, evolving public health guidelines, and growing distrust in institutions fueled anti-vaccine sentiment. In this opinion piece, we explore the paradoxical legacy of the COVID-19 vaccination campaign - how a global scientific triumph simultaneously gave rise to an emboldened anti-vaccine movement. Drawing on international data, we highlight the association between baseline vaccine acceptance and subsequent booster uptake and interpret these trends through the lens of the Health Belief Model. We further examine the psychological, cultural, political, and structural drivers of hesitancy and outline key strategies to rebuild public trust. Addressing this crisis requires proactive, evidence-informed, and culturally sensitive approaches to safeguard the future of global immunization efforts.
Keywords: COVID-19; SARS-CoV-2; anti-vaccine movement; public health; vaccines.