tetano
Editor, Senior Moderator
Hum Vaccin Immunother
. 2023 Jan 11;2153532.
doi: 10.1080/21645515.2022.2153532. Online ahead of print.
Emerging heterologous mRNA-based booster strategies within the COVID-19 vaccine landscape
Rituparna Das[SUP] 1 [/SUP], Randall N Hyer[SUP] 2 [/SUP], Paul Burton[SUP] 1 [/SUP], Jacqueline M Miller[SUP] 1 [/SUP], Barbara J Kuter[SUP] 1 [/SUP]
Affiliations
Abstract
Messenger RNA (mRNA)-based vaccine platforms used for the development of mRNA-1273 and BNT162b2 have provided a robust adaptable approach to offer protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, as variants of concern (VoCs), such as omicron and associated sub-variants, emerge, boosting strategies must also adapt to keep pace with the changing landscape. Heterologous vaccination regimens involving the administration of booster vaccines different than the primary vaccination series offer a practical, effective, and safe approach to continue to reduce the global burden of coronavirus disease 2019 (COVID-19). To understand the immunogenicity, effectiveness, and safety of heterologous mRNA-based vaccination strategies, relevant clinical and real-world observational studies were identified and summarized. Overall, heterologous boosting strategies with mRNA-based vaccines that are currently available and those in development will play an important global role in protecting individuals from COVID-19 caused by emerging VoCs.
Keywords: COVID-19; SARS-CoV-2; heterologous booster; mRNA-1273 vaccine.
. 2023 Jan 11;2153532.
doi: 10.1080/21645515.2022.2153532. Online ahead of print.
Emerging heterologous mRNA-based booster strategies within the COVID-19 vaccine landscape
Rituparna Das[SUP] 1 [/SUP], Randall N Hyer[SUP] 2 [/SUP], Paul Burton[SUP] 1 [/SUP], Jacqueline M Miller[SUP] 1 [/SUP], Barbara J Kuter[SUP] 1 [/SUP]
Affiliations
- PMID: 36629006
- DOI: 10.1080/21645515.2022.2153532
Abstract
Messenger RNA (mRNA)-based vaccine platforms used for the development of mRNA-1273 and BNT162b2 have provided a robust adaptable approach to offer protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, as variants of concern (VoCs), such as omicron and associated sub-variants, emerge, boosting strategies must also adapt to keep pace with the changing landscape. Heterologous vaccination regimens involving the administration of booster vaccines different than the primary vaccination series offer a practical, effective, and safe approach to continue to reduce the global burden of coronavirus disease 2019 (COVID-19). To understand the immunogenicity, effectiveness, and safety of heterologous mRNA-based vaccination strategies, relevant clinical and real-world observational studies were identified and summarized. Overall, heterologous boosting strategies with mRNA-based vaccines that are currently available and those in development will play an important global role in protecting individuals from COVID-19 caused by emerging VoCs.
Keywords: COVID-19; SARS-CoV-2; heterologous booster; mRNA-1273 vaccine.