tetano
Editor, Senior Moderator
Hum Genomics
. 2020 Jun 4;14(1):20.
doi: 10.1186/s40246-020-00272-6.
COVID-19 Preclinical Models: Human Angiotensin-Converting Enzyme 2 Transgenic Mice
Cathleen Lutz[SUP] 1 [/SUP], Leigh Maher[SUP] 2 [/SUP], Charles Lee[SUP] 2 3 [/SUP], Wonyoung Kang[SUP] 4 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is a declared pandemic that is spreading all over the world at a dreadfully fast rate. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the pathogen of COVID-19, infects the human body using angiotensin-converting enzyme 2 (ACE2) as a receptor identical to the severe acute respiratory syndrome (SARS) pandemic that occurred in 2002-2003. SARS-CoV-2 has a higher binding affinity to human ACE2 than to that of other species. Animal models that mimic the human disease are highly essential to develop therapeutics and vaccines against COVID-19. Here, we review transgenic mice that express human ACE2 in the airway and other epithelia and have shown to develop a rapidly lethal infection after intranasal inoculation with SARS-CoV, the pathogen of SARS. This literature review aims to present the importance of utilizing the human ACE2 transgenic mouse model to better understand the pathogenesis of COVID-19 and develop both therapeutics and vaccines.
Keywords: Angiotensin-converting enzyme 2 (ACE2); COVID-19; Coronavirus; SARS-CoV-2; Transgenic mouse.
. 2020 Jun 4;14(1):20.
doi: 10.1186/s40246-020-00272-6.
COVID-19 Preclinical Models: Human Angiotensin-Converting Enzyme 2 Transgenic Mice
Cathleen Lutz[SUP] 1 [/SUP], Leigh Maher[SUP] 2 [/SUP], Charles Lee[SUP] 2 3 [/SUP], Wonyoung Kang[SUP] 4 [/SUP]
Affiliations
- PMID: 32498696
- DOI: 10.1186/s40246-020-00272-6
Abstract
Coronavirus disease 2019 (COVID-19) is a declared pandemic that is spreading all over the world at a dreadfully fast rate. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the pathogen of COVID-19, infects the human body using angiotensin-converting enzyme 2 (ACE2) as a receptor identical to the severe acute respiratory syndrome (SARS) pandemic that occurred in 2002-2003. SARS-CoV-2 has a higher binding affinity to human ACE2 than to that of other species. Animal models that mimic the human disease are highly essential to develop therapeutics and vaccines against COVID-19. Here, we review transgenic mice that express human ACE2 in the airway and other epithelia and have shown to develop a rapidly lethal infection after intranasal inoculation with SARS-CoV, the pathogen of SARS. This literature review aims to present the importance of utilizing the human ACE2 transgenic mouse model to better understand the pathogenesis of COVID-19 and develop both therapeutics and vaccines.
Keywords: Angiotensin-converting enzyme 2 (ACE2); COVID-19; Coronavirus; SARS-CoV-2; Transgenic mouse.