tetano
Editor, Senior Moderator
Viruses. 2020 Mar 29;12(4). pii: E376. doi: 10.3390/v12040376.
Host-Virus Interaction: How Host Cells Defend against Influenza A Virus Infection.
Zhang Y[SUP]1[/SUP], Xu Z[SUP]1[/SUP], Cao Y[SUP]1[/SUP].
Author information
Abstract
Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and activated to restrict virus replication and clear pathogens. Subsequently, host adaptive immunity is involved in specific virus clearance. On the other hand, to achieve a successful infection, IAVs also apply multiple strategies to avoid be detected and eliminated by the host immunity. In the current review, we present a general description on recent work regarding different host cells and molecules facilitating antiviral defenses against IAV infection and how IAVs antagonize host immune responses.
KEYWORDS:
adaptive immunity; influenza A virus; innate immunity
PMID:32235330DOI:10.3390/v12040376
Free full text
Host-Virus Interaction: How Host Cells Defend against Influenza A Virus Infection.
Zhang Y[SUP]1[/SUP], Xu Z[SUP]1[/SUP], Cao Y[SUP]1[/SUP].
Author information
Abstract
Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and activated to restrict virus replication and clear pathogens. Subsequently, host adaptive immunity is involved in specific virus clearance. On the other hand, to achieve a successful infection, IAVs also apply multiple strategies to avoid be detected and eliminated by the host immunity. In the current review, we present a general description on recent work regarding different host cells and molecules facilitating antiviral defenses against IAV infection and how IAVs antagonize host immune responses.
KEYWORDS:
adaptive immunity; influenza A virus; innate immunity
PMID:32235330DOI:10.3390/v12040376
Free full text