tetano
Editor, Senior Moderator
Clinical Infectious Diseases
Hospitalized Patients with 2009 Pandemic Influenza A (H1N1) Virus Infection in the United States?September?October 2009
1. Jacek Skarbinski1,
2. Seema Jain2,
3. Anna Bramley2,
4. Esther J. Lee2,
5. Jean Huang2,
6. David Kirschke4,
7. Allison Stone5,
8. Tiffany Wedlake6,
9. Shawn M. Richards7,
10. Shannon Page8,
11. Patti Ragan9,
12. Lesley Bullion10,
13. Daniel Neises11,
14. Robin M. Williams12,
15. Bruno P. Petruccelli13,
16. Meredith Vandermeer14,
17. Kathryn H. Lofy15,
18. Jacqueline Gindler3,
19. Lyn Finelli2, and
20. for the 2009 Pandemic Influenza A (H1N1) Virus Fall Hospitalizations Investigation Team
+ Author Affiliations
1.
1Division of Parasitic Diseases and Malaria, Center for Global Health
2.
2Influenza Division, National Center for Immunization and Respiratory Diseases
3.
3Division of Birth Defects and Developmental Disabilities, and Centers for Disease Control and Prevention, Atlanta, Georgia
4.
4Tennessee Department of Health, Nashville, Tennessee
5.
5California Department of Public Health, Richmond, California
6.
6Department of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
7.
7Indiana State Department of Health, Indianapolis, Indiana
8.
8Ohio Department of Health, Columbus, Ohio
9.
9Florida Department of Health Bureau of Epidemiology, Tallahassee, Florida
10.
10Texas Department of State Health Services, Austin, Texas
11.
11Kansas Department of Health and Environment, Topeka, Kansas
12.
12Nebraska Department of Health and Human Services, Lincoln, Nebraska
13.
13Pennsylvania Department of Health, Harrisburg, Pennsylvania
14.
14Oregon Public Health Division, Portland, Oregon
15.
15Washington State Department of Health, Shoreline, Washington
1. Correspondence: Dr Jacek Skarbinski, Centers for Disease Control and Prevention, 4770 Buford Highway NE, MS-F22, Atlanta, GA 30341 (jskarbinski@cdc.gov).
Abstract
Given the potential worsening clinical severity of 2009 pandemic influenza A (H1N1) virus (pH1N1) infection from spring to fall 2009, we conducted a clinical case series among patients hospitalized with pH1N1 infection from September through October 2009. A case patient was defined as a hospitalized person who had test results positive for pH1N1 virus by real-time reverse-transcription polymerase chain reaction. Among 255 hospitalized patients, 34% were admitted to an intensive care unit and 8% died. Thirty-four percent of patients were children <18 years of age, 8% were adults ≥65 years of age, and 67% had an underlying medical condition. Chest radiographs obtained at hospital admission that had findings that were consistent with pneumonia were noted in 103 (46%) of 255 patients. Among 255 hospitalized patients, 208 (82%) received neuraminidase inhibitors, but only 47% had treatment started ≤2 days after illness onset. Overall, characteristics of hospitalized patients with pH1N1 infection in fall 2009 were similar to characteristics of patients hospitalized with pH1N1 infection in spring 2009, which suggests that clinical severity did not change substantially over this period.
http://cid.oxfordjournals.org/content/52/suppl_1/S50.full
Hospitalized Patients with 2009 Pandemic Influenza A (H1N1) Virus Infection in the United States?September?October 2009
1. Jacek Skarbinski1,
2. Seema Jain2,
3. Anna Bramley2,
4. Esther J. Lee2,
5. Jean Huang2,
6. David Kirschke4,
7. Allison Stone5,
8. Tiffany Wedlake6,
9. Shawn M. Richards7,
10. Shannon Page8,
11. Patti Ragan9,
12. Lesley Bullion10,
13. Daniel Neises11,
14. Robin M. Williams12,
15. Bruno P. Petruccelli13,
16. Meredith Vandermeer14,
17. Kathryn H. Lofy15,
18. Jacqueline Gindler3,
19. Lyn Finelli2, and
20. for the 2009 Pandemic Influenza A (H1N1) Virus Fall Hospitalizations Investigation Team
+ Author Affiliations
1.
1Division of Parasitic Diseases and Malaria, Center for Global Health
2.
2Influenza Division, National Center for Immunization and Respiratory Diseases
3.
3Division of Birth Defects and Developmental Disabilities, and Centers for Disease Control and Prevention, Atlanta, Georgia
4.
4Tennessee Department of Health, Nashville, Tennessee
5.
5California Department of Public Health, Richmond, California
6.
6Department of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
7.
7Indiana State Department of Health, Indianapolis, Indiana
8.
8Ohio Department of Health, Columbus, Ohio
9.
9Florida Department of Health Bureau of Epidemiology, Tallahassee, Florida
10.
10Texas Department of State Health Services, Austin, Texas
11.
11Kansas Department of Health and Environment, Topeka, Kansas
12.
12Nebraska Department of Health and Human Services, Lincoln, Nebraska
13.
13Pennsylvania Department of Health, Harrisburg, Pennsylvania
14.
14Oregon Public Health Division, Portland, Oregon
15.
15Washington State Department of Health, Shoreline, Washington
1. Correspondence: Dr Jacek Skarbinski, Centers for Disease Control and Prevention, 4770 Buford Highway NE, MS-F22, Atlanta, GA 30341 (jskarbinski@cdc.gov).
Abstract
Given the potential worsening clinical severity of 2009 pandemic influenza A (H1N1) virus (pH1N1) infection from spring to fall 2009, we conducted a clinical case series among patients hospitalized with pH1N1 infection from September through October 2009. A case patient was defined as a hospitalized person who had test results positive for pH1N1 virus by real-time reverse-transcription polymerase chain reaction. Among 255 hospitalized patients, 34% were admitted to an intensive care unit and 8% died. Thirty-four percent of patients were children <18 years of age, 8% were adults ≥65 years of age, and 67% had an underlying medical condition. Chest radiographs obtained at hospital admission that had findings that were consistent with pneumonia were noted in 103 (46%) of 255 patients. Among 255 hospitalized patients, 208 (82%) received neuraminidase inhibitors, but only 47% had treatment started ≤2 days after illness onset. Overall, characteristics of hospitalized patients with pH1N1 infection in fall 2009 were similar to characteristics of patients hospitalized with pH1N1 infection in spring 2009, which suggests that clinical severity did not change substantially over this period.
http://cid.oxfordjournals.org/content/52/suppl_1/S50.full