Giuseppe
Emeritus
Highly pathogenic avian influenza virus (H5N1) infection in red foxes fed infected bird carcasses. [EID CDC]
Highly pathogenic avian influenza virus (H5N1) infection in red foxes fed infected bird carcasses.
DOI: 10.3201/eid1412.080470
Suggested citation for this article: Reperant LA, van Amerongen G, van de Bildt MWG, Rimmelzwaan GF, Dobson AP, Osterhaus ADME, et al. Highly pathogenic avian influenza virus (H5N1) infection in red foxes fed infected bird carcasses. Emerg Infect Dis. 2008 Dec; [Epub ahead of print]
Highly Pathogenic Avian Influenza Virus (H5N1) Infection in Red Foxes Fed Infected Bird Carcasses
Leslie A. Reperant, Geert van Amerongen, Marco W.G. van de Bildt, Guus F. Rimmelzwaan, Andrew P. Dobson, Albert D.M.E. Osterhaus, and Thijs Kuiken - Author affiliations: Princeton University, Princeton, New Jersey, USA (L.A. Reperant, A.P. Dobson); and Erasmus Medical Centre, Rotterdam, the Netherlands (G. van Amerongen, M.W.G. van de Bildt, G.F. Rimmelzwaan, A.D.M.E. Osterhaus, T. Kuiken)
Eating infected wild birds may put wild carnivores at high risk for infection with highly pathogenic avian influenza (HPAI) virus (H5N1).
To determine whether red foxes (Vulpes vulpes) are susceptible to infection with HPAI virus (H5N1), we infected 3 foxes intratracheally.
They excreted virus pharyngeally for 3?7 days at peak titers of 103.5?105.2 median tissue culture infective dose (TCID50) per mL; they became ill with severe pneumonia, myocarditis, and encephalitis.
To determine whether foxes can become infected by the presumed natural route, we fed infected bird carcasses to 3 other red foxes.
These foxes excreted virus pharyngeally for 3?5 days at peak titers of 104.2?104.5 TCID50/mL, but only mild or no pneumonia developed.
This study demonstrates that red foxes fed bird carcasses infected with HPAI virus (H5N1) can excrete virus while remaining free of severe disease, thereby potentially playing a role in virus dispersal.
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Full text: http://www.cdc.gov/eid/content/14/12/pdfs/08-0470.pdf
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Highly pathogenic avian influenza virus (H5N1) infection in red foxes fed infected bird carcasses.
DOI: 10.3201/eid1412.080470
Suggested citation for this article: Reperant LA, van Amerongen G, van de Bildt MWG, Rimmelzwaan GF, Dobson AP, Osterhaus ADME, et al. Highly pathogenic avian influenza virus (H5N1) infection in red foxes fed infected bird carcasses. Emerg Infect Dis. 2008 Dec; [Epub ahead of print]
Highly Pathogenic Avian Influenza Virus (H5N1) Infection in Red Foxes Fed Infected Bird Carcasses
Leslie A. Reperant, Geert van Amerongen, Marco W.G. van de Bildt, Guus F. Rimmelzwaan, Andrew P. Dobson, Albert D.M.E. Osterhaus, and Thijs Kuiken - Author affiliations: Princeton University, Princeton, New Jersey, USA (L.A. Reperant, A.P. Dobson); and Erasmus Medical Centre, Rotterdam, the Netherlands (G. van Amerongen, M.W.G. van de Bildt, G.F. Rimmelzwaan, A.D.M.E. Osterhaus, T. Kuiken)
Eating infected wild birds may put wild carnivores at high risk for infection with highly pathogenic avian influenza (HPAI) virus (H5N1).
To determine whether red foxes (Vulpes vulpes) are susceptible to infection with HPAI virus (H5N1), we infected 3 foxes intratracheally.
They excreted virus pharyngeally for 3?7 days at peak titers of 103.5?105.2 median tissue culture infective dose (TCID50) per mL; they became ill with severe pneumonia, myocarditis, and encephalitis.
To determine whether foxes can become infected by the presumed natural route, we fed infected bird carcasses to 3 other red foxes.
These foxes excreted virus pharyngeally for 3?5 days at peak titers of 104.2?104.5 TCID50/mL, but only mild or no pneumonia developed.
This study demonstrates that red foxes fed bird carcasses infected with HPAI virus (H5N1) can excrete virus while remaining free of severe disease, thereby potentially playing a role in virus dispersal.
-
Full text: http://www.cdc.gov/eid/content/14/12/pdfs/08-0470.pdf
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