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Highly multidrug-resistant Gram-negative bacterial infections in war victims in Ukraine, 2022 - The Lancet

Mary Wilson

Well-known member
Published: May 23, 2023

DOI: https://doi.org/10.1016/S1473-3099(23)00291-8

Oskar Ljungquist, Oleksandr Nazarchuk, Gunnar Kahlmeter, Vigith Andrews, Thalea Koithan, Lisa Wasserstrom, et al.​

From 2014 to 2020, higher rates of antimicrobial resistance were reported in military hospitals than in civilian hospitals in Ukraine, indicating the challenges associated with reducing the spread of antibiotic-resistant bacteria during conflict.[SUP]1[/SUP] Identical clones of carbapenem-resistant isolates of the Acinetobacter baumanniicomplex has been described by a 2016 study in Ukrainian war victims treated in Germany, suggesting a possible spread in Ukrainian hospitals.[SUP]2[/SUP]

To monitor the prevalence of antimicrobial-resistant infections in Ukraine, we conducted sentinel testing of hospitalised war victims with hospital-associated infections between February and September, 2022. The patients included in this study were those who required emergency surgery and intensive care due to severe burns, shrapnel wounds, and fractures. Swabs were taken from the skin and soft tissue of patients when signs of infection were observed in wounds or burn surfaces. Catheter tips from central venous catheters showing signs of infection were sent to the microbiology department for culture. Additionally, tracheobronchial aspirates were collected from patients with signs of ventilator-associated pneumonia who had received respiratory support for more than 72 h.​

Because of resource limitations in Ukraine, the isolates were analysed at Lund University's clinical microbiology laboratory, followed by antibiotic susceptibility testing at the European Committee on Antimicrobial Susceptibility Testing (EUCAST) development laboratory. ...

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00291-8/fulltext
 
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