tetano
Editor, Senior Moderator
High Alt Med Biol
. 2023 Feb 9.
doi: 10.1089/ham.2022.0062. Online ahead of print.
Effect of Altitude on Respiratory Functional Status in COVID-19 Survivors: Results from a Latin American Cohort-FIRCOV
Laura Gochicoa-Rangel[SUP] 1 [/SUP], Santiago C Arce[SUP] 2 [/SUP], Carlos Aguirre-Franco[SUP] 3 [/SUP], Wilmer Madrid-Mejía[SUP] 1 [/SUP], Mónica Gutiérrez-Clavería[SUP] 4 [/SUP], Lorena Noriega-Aguirre[SUP] 5 [/SUP], Patricia Schonffeldt-Guerrero[SUP] 6 [/SUP], Agustín Acuña-Izcaray[SUP] 7 [/SUP], Arturo Cortés-Telles[SUP] 8 [/SUP], Luisa Martínez-Valdeavellano[SUP] 9 [/SUP], Federico Isaac Hernández-Rocha[SUP] 10 [/SUP], Omar Ceballos-Zúñiga[SUP] 10 11 [/SUP], Rodrigo Del Rio Hidalgo[SUP] 12 [/SUP], Sonia Sánchez[SUP] 13 [/SUP], Erika Meneses-Tamayo[SUP] 1 [/SUP], Iván Chérrez-Ojeda[SUP] 14 15 [/SUP]; Respiratory Physiology Project in COVID-19 (FIRCOV)
Collaborators, Affiliations
Abstract
Laura Gochicoa-Rangel, Santiago C. Arce, Carlos Aguirre-Franco, Wilmer Madrid-Mejía, Mónica Gutiérrez-Clavería, Lorena Noriega-Aguirre, Patricia Schonffeldt-Guerrero, Agustín Acuña-Izcaray, Arturo Cortés-Telles, Luisa Martínez-Valdeavellano, Federico Isaac Hernández-Rocha, Omar Ceballos-Zúñiga, Rodrigo Del Rio Hidalgo, Sonia Sánchez, Erika Meneses-Tamayo, and Iván Chérrez-Ojeda; and on Behalf of the Respiratory Physiology Project in COVID-19 (FIRCOV). Effect of altitude on respiratory functional status in COVID-19 survivors: results from a Latin American Cohort-FIRCOV. High Alt Med Biol XX:XXX-XXX, 2023. Persistent symptoms and lung function abnormalities are common in COVID-19 survivors. Objectives: To determine the effect of altitude and other independent variables on respiratory function in COVID-19 survivors. Methods: Analytical, observational, cross-sectional cohort study done at 13 medical centers in Latin America located at different altitudes above sea level. COVID-19 survivors were invited to perform pulmonary function tests at least 3 weeks after diagnosis. Results: 1,368 participants (59% male) had mild (20%), moderate (59%), and severe (21%) disease. Restriction by spirometry was noted in 32%; diffusing capacity of the lung for carbon monoxide (DLCO) was low in 43.7%; and 22.2% walked less meters during the 6-minute walk test (6-MWT). In multiple linear regression models, higher altitude was associated with better spirometry, DLCO and 6-MWT, but lower oxygen saturation at rest and during exercise. Men were 3 times more likely to have restriction and 5.7 times more likely to have a low DLCO. Those who had required mechanical ventilation had lower DLCO and walked less during the 6-MWT. Conclusions: Men were more likely to have lower lung function than women, even after correcting for disease severity and other factors. Patients living at a higher altitude were more likely to have better spirometric patterns and walked farther but had lower DLCO and oxygen saturation.
Keywords: 6-minute walk test; COVID-19 and coronavirus disease; altitude; pulmonary diffusing capacity and DLCO; respiratory function tests.
. 2023 Feb 9.
doi: 10.1089/ham.2022.0062. Online ahead of print.
Effect of Altitude on Respiratory Functional Status in COVID-19 Survivors: Results from a Latin American Cohort-FIRCOV
Laura Gochicoa-Rangel[SUP] 1 [/SUP], Santiago C Arce[SUP] 2 [/SUP], Carlos Aguirre-Franco[SUP] 3 [/SUP], Wilmer Madrid-Mejía[SUP] 1 [/SUP], Mónica Gutiérrez-Clavería[SUP] 4 [/SUP], Lorena Noriega-Aguirre[SUP] 5 [/SUP], Patricia Schonffeldt-Guerrero[SUP] 6 [/SUP], Agustín Acuña-Izcaray[SUP] 7 [/SUP], Arturo Cortés-Telles[SUP] 8 [/SUP], Luisa Martínez-Valdeavellano[SUP] 9 [/SUP], Federico Isaac Hernández-Rocha[SUP] 10 [/SUP], Omar Ceballos-Zúñiga[SUP] 10 11 [/SUP], Rodrigo Del Rio Hidalgo[SUP] 12 [/SUP], Sonia Sánchez[SUP] 13 [/SUP], Erika Meneses-Tamayo[SUP] 1 [/SUP], Iván Chérrez-Ojeda[SUP] 14 15 [/SUP]; Respiratory Physiology Project in COVID-19 (FIRCOV)
Collaborators, Affiliations
- PMID: 36757307
- DOI: 10.1089/ham.2022.0062
Abstract
Laura Gochicoa-Rangel, Santiago C. Arce, Carlos Aguirre-Franco, Wilmer Madrid-Mejía, Mónica Gutiérrez-Clavería, Lorena Noriega-Aguirre, Patricia Schonffeldt-Guerrero, Agustín Acuña-Izcaray, Arturo Cortés-Telles, Luisa Martínez-Valdeavellano, Federico Isaac Hernández-Rocha, Omar Ceballos-Zúñiga, Rodrigo Del Rio Hidalgo, Sonia Sánchez, Erika Meneses-Tamayo, and Iván Chérrez-Ojeda; and on Behalf of the Respiratory Physiology Project in COVID-19 (FIRCOV). Effect of altitude on respiratory functional status in COVID-19 survivors: results from a Latin American Cohort-FIRCOV. High Alt Med Biol XX:XXX-XXX, 2023. Persistent symptoms and lung function abnormalities are common in COVID-19 survivors. Objectives: To determine the effect of altitude and other independent variables on respiratory function in COVID-19 survivors. Methods: Analytical, observational, cross-sectional cohort study done at 13 medical centers in Latin America located at different altitudes above sea level. COVID-19 survivors were invited to perform pulmonary function tests at least 3 weeks after diagnosis. Results: 1,368 participants (59% male) had mild (20%), moderate (59%), and severe (21%) disease. Restriction by spirometry was noted in 32%; diffusing capacity of the lung for carbon monoxide (DLCO) was low in 43.7%; and 22.2% walked less meters during the 6-minute walk test (6-MWT). In multiple linear regression models, higher altitude was associated with better spirometry, DLCO and 6-MWT, but lower oxygen saturation at rest and during exercise. Men were 3 times more likely to have restriction and 5.7 times more likely to have a low DLCO. Those who had required mechanical ventilation had lower DLCO and walked less during the 6-MWT. Conclusions: Men were more likely to have lower lung function than women, even after correcting for disease severity and other factors. Patients living at a higher altitude were more likely to have better spirometric patterns and walked farther but had lower DLCO and oxygen saturation.
Keywords: 6-minute walk test; COVID-19 and coronavirus disease; altitude; pulmonary diffusing capacity and DLCO; respiratory function tests.