tetano
Editor, Senior Moderator
Cell Rep. 2019 Nov 19;29(8):2243-2256.e4. doi: 10.1016/j.celrep.2019.10.051. [h=1]Helminth Infections Suppress the Efficacy of Vaccination against Seasonal Influenza.[/h]
Hartmann W[SUP]1[/SUP], Brunn ML[SUP]1[/SUP], Stetter N[SUP]1[/SUP], Gagliani N[SUP]2[/SUP], Muscate F[SUP]3[/SUP], Stanelle-Bertram S[SUP]4[/SUP], Gabriel G[SUP]5[/SUP], Breloer M[SUP]6[/SUP].
[h=3]Author information[/h] 1 Section for Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany. 2 I Department of Medicine and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden. 3 I Department of Medicine and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. 4 Research Department for Viral Zoonoses-One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany. 5 Research Department for Viral Zoonoses-One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany; Institute for Virology, University for Veterinary Medicine, Hannover, Germany. 6 Section for Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany. Electronic address: breloer@bnitm.de.
[h=3]Abstract[/h] Helminth parasites infect more than a quarter of the human population and inflict significant changes to the immunological status of their hosts. Here, we analyze the impact of helminth infections on the efficacy of vaccinations using Litomosoides sigmodontis-infected mice. Concurrent helminth infection reduces the quantity and quality of antibody responses to vaccination against seasonal influenza. Vaccination-induced protection against challenge infections with the human pathogenic 2009 pandemic H1N1 influenza A virus is drastically impaired in helminth-infected mice. Impaired responses are also observed if vaccinations are performed after clearance of a previous helminth infection, suggesting that individuals in helminth-endemic areas may not always benefit from vaccinations, even in the absence of an acute and diagnosable helminth infection. Mechanistically, the suppression is associated with a systemic and sustained expansion of interleukin (IL)-10-producing CD4[SUP]+[/SUP]CD49[SUP]+[/SUP]LAG-3[SUP]+[/SUP] type 1 regulatory T cells and partially abrogated by in vivo blockade of the IL-10 receptor.
Copyright ? 2019 The Authors. Published by Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Foxp3(+) regulatory T cells; Litomosoides sigmodontis; antibody response; helminth; immunomodulation; influenza; interleukin-10; parasite infection; type 1 regulatory T cells; vaccination efficacy
PMID: 31747598 DOI: 10.1016/j.celrep.2019.10.051
Hartmann W[SUP]1[/SUP], Brunn ML[SUP]1[/SUP], Stetter N[SUP]1[/SUP], Gagliani N[SUP]2[/SUP], Muscate F[SUP]3[/SUP], Stanelle-Bertram S[SUP]4[/SUP], Gabriel G[SUP]5[/SUP], Breloer M[SUP]6[/SUP].
[h=3]Author information[/h] 1 Section for Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany. 2 I Department of Medicine and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden. 3 I Department of Medicine and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. 4 Research Department for Viral Zoonoses-One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany. 5 Research Department for Viral Zoonoses-One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany; Institute for Virology, University for Veterinary Medicine, Hannover, Germany. 6 Section for Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany. Electronic address: breloer@bnitm.de.
[h=3]Abstract[/h] Helminth parasites infect more than a quarter of the human population and inflict significant changes to the immunological status of their hosts. Here, we analyze the impact of helminth infections on the efficacy of vaccinations using Litomosoides sigmodontis-infected mice. Concurrent helminth infection reduces the quantity and quality of antibody responses to vaccination against seasonal influenza. Vaccination-induced protection against challenge infections with the human pathogenic 2009 pandemic H1N1 influenza A virus is drastically impaired in helminth-infected mice. Impaired responses are also observed if vaccinations are performed after clearance of a previous helminth infection, suggesting that individuals in helminth-endemic areas may not always benefit from vaccinations, even in the absence of an acute and diagnosable helminth infection. Mechanistically, the suppression is associated with a systemic and sustained expansion of interleukin (IL)-10-producing CD4[SUP]+[/SUP]CD49[SUP]+[/SUP]LAG-3[SUP]+[/SUP] type 1 regulatory T cells and partially abrogated by in vivo blockade of the IL-10 receptor.
Copyright ? 2019 The Authors. Published by Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Foxp3(+) regulatory T cells; Litomosoides sigmodontis; antibody response; helminth; immunomodulation; influenza; interleukin-10; parasite infection; type 1 regulatory T cells; vaccination efficacy
PMID: 31747598 DOI: 10.1016/j.celrep.2019.10.051