tetano
Editor, Senior Moderator
Heliyon
. 2023 Dec 14;10(1):e23662.
doi: 10.1016/j.heliyon.2023.e23662. eCollection 2024 Jan 15. Association of genetic polymorphisms with COVID-19 infection and outcomes: An updated meta-analysis based on 62 studies
Hongyue Ren[SUP] 1 [/SUP], Yanyan Lin[SUP] 1 [/SUP], Lifeng Huang[SUP] 1 [/SUP], Wenxin Xu[SUP] 2 [/SUP], Deqing Luo[SUP] 3 [/SUP], Chunbin Zhang[SUP] 2 [/SUP]
Affiliations
Background: The relationship between genetic polymorphisms and coronavirus disease 2019 (COVID-19) remains to be inconsistent. This meta-analysis aimed to provide an updated evaluation of the role of genetic polymorphisms in the infection, severity and mortality of COVID-19 based on all available published studies.
Methods: A systematic search was performed using six databases: PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Wanfang. Summary odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were used to calculate the genotypic comparison. All statistical analyses were conducted in Stata 12.0.
Results: A total of 62 studies with 19600 cases and 28899 controls was included in this meta-analysis. For COVID-19 infection, ACE Ins/Del polymorphism might be related with significantly decreased risk of COVID-19 infection under dominant, homozygote and allelic models. Meanwhile, the IFITM3 rs12252 and TMPRSS2 rs12329760 polymorphisms were significantly associated with the increased risk of COVID-19 infection under one or more models. Regarding COVID-19 severity, ACE2 rs2074192, ACE2 rs2106809, IFITM3 rs12252 and VDR rs1544410 polymorphisms might be related with significantly increased risk of COVID-19 severity in one or more models. Moreover, the analysis of TMPRSS2 rs2070788 indicated that a variant A allele decreased the risk of COVID-19 severity in recessive model. For COVID-19 mortality, the variant C allele of IFITM3 rs12252 polymorphism might be related with significantly increased risk of COVID-19 mortality under all genetic models.
Conclusions: This meta-analysis indicated that he infection, severity or mortality of COVID-19 were related to the above genetic polymorphisms, which might provide an important theoretical basis for understanding the clinical feature of COVID-19 disease.
Keywords: COVID-19; Genetic polymorphisms; Infection; Outcomes; meta-analysis.
. 2023 Dec 14;10(1):e23662.
doi: 10.1016/j.heliyon.2023.e23662. eCollection 2024 Jan 15. Association of genetic polymorphisms with COVID-19 infection and outcomes: An updated meta-analysis based on 62 studies
Hongyue Ren[SUP] 1 [/SUP], Yanyan Lin[SUP] 1 [/SUP], Lifeng Huang[SUP] 1 [/SUP], Wenxin Xu[SUP] 2 [/SUP], Deqing Luo[SUP] 3 [/SUP], Chunbin Zhang[SUP] 2 [/SUP]
Affiliations
- PMID: 38187247
- PMCID: PMC10767390
- DOI: 10.1016/j.heliyon.2023.e23662
Background: The relationship between genetic polymorphisms and coronavirus disease 2019 (COVID-19) remains to be inconsistent. This meta-analysis aimed to provide an updated evaluation of the role of genetic polymorphisms in the infection, severity and mortality of COVID-19 based on all available published studies.
Methods: A systematic search was performed using six databases: PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Wanfang. Summary odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were used to calculate the genotypic comparison. All statistical analyses were conducted in Stata 12.0.
Results: A total of 62 studies with 19600 cases and 28899 controls was included in this meta-analysis. For COVID-19 infection, ACE Ins/Del polymorphism might be related with significantly decreased risk of COVID-19 infection under dominant, homozygote and allelic models. Meanwhile, the IFITM3 rs12252 and TMPRSS2 rs12329760 polymorphisms were significantly associated with the increased risk of COVID-19 infection under one or more models. Regarding COVID-19 severity, ACE2 rs2074192, ACE2 rs2106809, IFITM3 rs12252 and VDR rs1544410 polymorphisms might be related with significantly increased risk of COVID-19 severity in one or more models. Moreover, the analysis of TMPRSS2 rs2070788 indicated that a variant A allele decreased the risk of COVID-19 severity in recessive model. For COVID-19 mortality, the variant C allele of IFITM3 rs12252 polymorphism might be related with significantly increased risk of COVID-19 mortality under all genetic models.
Conclusions: This meta-analysis indicated that he infection, severity or mortality of COVID-19 were related to the above genetic polymorphisms, which might provide an important theoretical basis for understanding the clinical feature of COVID-19 disease.
Keywords: COVID-19; Genetic polymorphisms; Infection; Outcomes; meta-analysis.