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2013. 11.19
45th Annual Meeting of the Japanese Society for Pediatric Infectious Diseases
H7N9 avian influenza virus has ability cause pandemic
Institute of Medical Science, Professor Kawaoka pointed out
Hiroshi Takahashi = Medical Writers
According to the WHO announcement of November 6, new in China avian influenza A (H7N9) virus patients infected with occurred two. Reached the flu season, trend is great attention. The characteristics of the H7N9 virus, the 45th Yoshihiro Kawaoka of the University of Tokyo's Institute of Medical Science, infection and immunology department virus infection research field Professor, recent results Japan Society for Pediatric Infectious Diseases , the General Assembly Annual Meeting (October 26 - 27th Place: reported in Sapporo). That the H7N9 strain has a property that is easy to droplet infection is observed, mainly because air infection is established while limited in ferrets between, H7N9 virus was pointed out that, "said the virus with the ability to cause a pandemic". If you include the two patients, which was announced on November 6, H7N9 virus human infection cases by WHO confirmed so far 139 cases. 45 cases of which have been fatal, fatality rate was 32.4%. Currently, it is six people, including one example severe announced November 6 and hospitalized. At present, there is no evidence of infection to humans comes after from people. However, limited human - human infection case has been confirmed. "Corresponds to the risk assessment of outbreaks of avian influenza A by (H7N9) virus," the National Institute of Infectious Diseases in the (November 5 updated version), people with "limited - it has been pointed out human infection is going on you are from, secondary infection and "can occur, such as within the family from infection who arrived in the country. If you examine the H7N9-infected patients, the context of (60s peak) male, aged relatively emerge. View that for the man who retired and out of the live bird market is often strong. It closed the raw bird market early patient after the occurrence, the Chinese government carried out disinfection and culling, such as chicken. The number of patients decreased significantly to machine it. However, raw bird some markets has been resumed recently.
Further, it is inferred from the temperature had come down, infections and or not than began to occur again from the end of October. What worried above all would be (large global epidemic) pandemic. This time, Mr. Kawaoka revealed that joint research from the University of Tokyo, National Institute of Infectious Diseases, Hokkaido University, and the United States Scripps Research Institute, has the property that H7N9 virus can cause a pandemic. First, we examined the growth of the respiratory, H7N9 virus has been found that compared to (H1N1) seasonal influenza virus, respiratory monkey, to grow strongly, especially in the lungs. There was no growth as H1N1pdm09 that caused a pandemic in 2009, proliferative in the lung showed more than 1000 times the H1N1 virus seasonal. The reason why the death rate of H7N9 infected patients is high, various factors have been pointed out, but Kawaoka, unlike a virus of "seasonal, H7N9 virus is because increase well in people as one of the reasons from this data I pointed out that low ".
Meanwhile, in order to cause a pandemic, needing virus to grow efficiently in the upper respiratory tract of the infected patients. Through coughing or sneezing, and because more likely to spread to the people around. Influenza virus, is recognized as the receptor sugar chains with a terminal sialic acid, but in the avian influenza virus and a human influenza virus, sialic acid to recognize slightly different. Whereas recognize what sialic acid is α2-6 bound to galactose, avian influenza virus to recognize that sialic acid is α2-3 binds to galactose human influenza virus. Previously, in collaboration with the Netherlands, receptor α2-6 linked sialic acid is found many such as upper respiratory tract is over from the lungs of respiratory humans, Kawaoka and his colleagues α2-6 linked sialic acid in the lung I have shown that not only receptors, receptor α2-3 linked sialic acid is also present. For this reason, avian influenza virus of the highly pathogenic H5N1, such as to cause severe pneumonia is infected with human lung. However, in order for the virus to efficiently droplet infection, recognizing the receptor α2-6 linked sialic acids there are many in the upper respiratory tract is required. The amino Several HA, it is important for the recognition of α2-6 linked sialic acid is known. The one of which amino acids 226 th majority of H7N9 viruses isolated from Chinese patients had become leucine or isoleucine. Kawaoka and his colleagues, examined the receptor specificity of various influenza viruses, including H7N9. Then, H1N1 virus of seasonal and number attached to the sugar chain with a α2-6 linked sialic acid, H5N1 virus bound many sugar chains with α2-3 linked sialic acid. H7N9 Anhui / 1 share with a leucine to 226 of the amino acid, H7N9 Hangzhou / 1 strains and with isoleucine, the latter has been found that a large number linked to the sugar chain with a α2-6 linked sialic acid in particular. The H7N9 Shanghai / 1 share of glutamine, binding of many was observed in any sugar chains with α2-3 linked sialic acid, a sugar chain with α2-6 linked sialic acid 226 of the amino acid. In addition, we examined ferrets three sets of the ease of air caused infection of each virus, infection is established with three sets in H1N1pdm09, infection did not occur in all three sets of H5N1 virus. With respect to this, infection is established in pairs three sets of H7N9 virus in (Anhui / 1 share), prone to droplet infection from H5N1 virus has been shown. These results were similar to the research groups of five world. These results, and is a virus that is estimated to some extent, "H7N9 virus is propagated in mammals between already, droplet infection than the H5N1 virus, and easy-to-air infection at least, have the ability to cause a pandemic Kawaoka Mr. It was concluded that, "said.
http://medical.nikkeibp.co.jp/leaf/all/special/pandemic/topics/201311/533624.html
2013. 11.19
45th Annual Meeting of the Japanese Society for Pediatric Infectious Diseases
H7N9 avian influenza virus has ability cause pandemic
Institute of Medical Science, Professor Kawaoka pointed out
Hiroshi Takahashi = Medical Writers
According to the WHO announcement of November 6, new in China avian influenza A (H7N9) virus patients infected with occurred two. Reached the flu season, trend is great attention. The characteristics of the H7N9 virus, the 45th Yoshihiro Kawaoka of the University of Tokyo's Institute of Medical Science, infection and immunology department virus infection research field Professor, recent results Japan Society for Pediatric Infectious Diseases , the General Assembly Annual Meeting (October 26 - 27th Place: reported in Sapporo). That the H7N9 strain has a property that is easy to droplet infection is observed, mainly because air infection is established while limited in ferrets between, H7N9 virus was pointed out that, "said the virus with the ability to cause a pandemic". If you include the two patients, which was announced on November 6, H7N9 virus human infection cases by WHO confirmed so far 139 cases. 45 cases of which have been fatal, fatality rate was 32.4%. Currently, it is six people, including one example severe announced November 6 and hospitalized. At present, there is no evidence of infection to humans comes after from people. However, limited human - human infection case has been confirmed. "Corresponds to the risk assessment of outbreaks of avian influenza A by (H7N9) virus," the National Institute of Infectious Diseases in the (November 5 updated version), people with "limited - it has been pointed out human infection is going on you are from, secondary infection and "can occur, such as within the family from infection who arrived in the country. If you examine the H7N9-infected patients, the context of (60s peak) male, aged relatively emerge. View that for the man who retired and out of the live bird market is often strong. It closed the raw bird market early patient after the occurrence, the Chinese government carried out disinfection and culling, such as chicken. The number of patients decreased significantly to machine it. However, raw bird some markets has been resumed recently.
Further, it is inferred from the temperature had come down, infections and or not than began to occur again from the end of October. What worried above all would be (large global epidemic) pandemic. This time, Mr. Kawaoka revealed that joint research from the University of Tokyo, National Institute of Infectious Diseases, Hokkaido University, and the United States Scripps Research Institute, has the property that H7N9 virus can cause a pandemic. First, we examined the growth of the respiratory, H7N9 virus has been found that compared to (H1N1) seasonal influenza virus, respiratory monkey, to grow strongly, especially in the lungs. There was no growth as H1N1pdm09 that caused a pandemic in 2009, proliferative in the lung showed more than 1000 times the H1N1 virus seasonal. The reason why the death rate of H7N9 infected patients is high, various factors have been pointed out, but Kawaoka, unlike a virus of "seasonal, H7N9 virus is because increase well in people as one of the reasons from this data I pointed out that low ".
Meanwhile, in order to cause a pandemic, needing virus to grow efficiently in the upper respiratory tract of the infected patients. Through coughing or sneezing, and because more likely to spread to the people around. Influenza virus, is recognized as the receptor sugar chains with a terminal sialic acid, but in the avian influenza virus and a human influenza virus, sialic acid to recognize slightly different. Whereas recognize what sialic acid is α2-6 bound to galactose, avian influenza virus to recognize that sialic acid is α2-3 binds to galactose human influenza virus. Previously, in collaboration with the Netherlands, receptor α2-6 linked sialic acid is found many such as upper respiratory tract is over from the lungs of respiratory humans, Kawaoka and his colleagues α2-6 linked sialic acid in the lung I have shown that not only receptors, receptor α2-3 linked sialic acid is also present. For this reason, avian influenza virus of the highly pathogenic H5N1, such as to cause severe pneumonia is infected with human lung. However, in order for the virus to efficiently droplet infection, recognizing the receptor α2-6 linked sialic acids there are many in the upper respiratory tract is required. The amino Several HA, it is important for the recognition of α2-6 linked sialic acid is known. The one of which amino acids 226 th majority of H7N9 viruses isolated from Chinese patients had become leucine or isoleucine. Kawaoka and his colleagues, examined the receptor specificity of various influenza viruses, including H7N9. Then, H1N1 virus of seasonal and number attached to the sugar chain with a α2-6 linked sialic acid, H5N1 virus bound many sugar chains with α2-3 linked sialic acid. H7N9 Anhui / 1 share with a leucine to 226 of the amino acid, H7N9 Hangzhou / 1 strains and with isoleucine, the latter has been found that a large number linked to the sugar chain with a α2-6 linked sialic acid in particular. The H7N9 Shanghai / 1 share of glutamine, binding of many was observed in any sugar chains with α2-3 linked sialic acid, a sugar chain with α2-6 linked sialic acid 226 of the amino acid. In addition, we examined ferrets three sets of the ease of air caused infection of each virus, infection is established with three sets in H1N1pdm09, infection did not occur in all three sets of H5N1 virus. With respect to this, infection is established in pairs three sets of H7N9 virus in (Anhui / 1 share), prone to droplet infection from H5N1 virus has been shown. These results were similar to the research groups of five world. These results, and is a virus that is estimated to some extent, "H7N9 virus is propagated in mammals between already, droplet infection than the H5N1 virus, and easy-to-air infection at least, have the ability to cause a pandemic Kawaoka Mr. It was concluded that, "said.
http://medical.nikkeibp.co.jp/leaf/all/special/pandemic/topics/201311/533624.html