Growth and pathogenic potential of naturally selected reassortants after co-infection with pandemic H1N1 and HPAI H5N1 viruses

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J Virol. 2015 Oct 21. pii: JVI.01572-15. [Epub ahead of print]
[h=1]Growth and pathogenic potential of naturally selected reassortants after co-infection with pandemic H1N1 and HPAI H5N1 viruses.[/h] Song MS[SUP]1[/SUP], Baek YH[SUP]1[/SUP], Pascua PN[SUP]1[/SUP], Kwon HI[SUP]1[/SUP], Kim EH[SUP]1[/SUP], Park SJ[SUP]1[/SUP], Kim SM[SUP]1[/SUP], Kim YI[SUP]1[/SUP], Choi WS[SUP]1[/SUP], Kim EG[SUP]1[/SUP], Kim CJ[SUP]2[/SUP], Choi YK[SUP]3[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] Co-infected of ferrets with H5N1 and pH1N1 viruses resulted in two predominate-genotypes in the lungs containing surface gene/s of highly pathogenic avian influenza H5N1 virus in the backbone of pandemic H1N1 2009 (pH1N1). Compared to parental strains, these reassortants exhibited increased growth and virulence in vitro and in mice, but failed to transmit indirectly to na?ve contact ferrets. Thus, this demonstrates a possible natural reassortment following co-infection as well as the pathogenicity of the potential reassortants.
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PMID: 26491154 [PubMed - as supplied by publisher]