tetano
Editor, Senior Moderator
Gerontology
. 2020 May 29;1-9.
doi: 10.1159/000508734. Online ahead of print.
Clinical Characteristics of Elderly Patients With COVID-19 in Hunan Province, China: A Multicenter, Retrospective Study
Ting Guo[SUP] 1 2 3 [/SUP], Qinxue Shen[SUP] 1 2 3 [/SUP], Wei Guo[SUP] 1 2 3 [/SUP], Wenlong He[SUP] 1 2 3 [/SUP], Jinhua Li[SUP] 1 2 3 [/SUP], Yi Zhang[SUP] 1 2 3 [/SUP], Yunnian Wang[SUP] 4 [/SUP], Zhiguo Zhou[SUP] 5 [/SUP], Dingding Deng[SUP] 6 [/SUP], Xiaoli Ouyang[SUP] 1 2 3 [/SUP], Zhi Xiang[SUP] 7 [/SUP], Minyan Jiang[SUP] 8 [/SUP], Minyong Liang[SUP] 9 [/SUP], Peng Huang[SUP] 10 [/SUP], Zaimei Peng[SUP] 11 [/SUP], Xudong Xiang[SUP] 11 [/SUP], Wenlong Liu[SUP] 12 [/SUP], Hong Luo[SUP] 1 2 3 [/SUP], Ping Chen[SUP] 1 2 3 [/SUP], Hong Peng[SUP] 13 14 15 [/SUP]
Affiliations
Abstract
Background: The aim of this study was to analyze and summarize the clinical characteristics of elderly patients with coronavirus disease 2019 (COVID-19) and compare the differences of young-old patients (60-74 years old) and old-old patients (≥75 years old).
Methods: In thisretrospective, multicenter study, the medical records of elderly patients who were diagnosed with COVID-19 in Hunan province, China, from January 21 to February 19, 2020 were reviewed. The characteristics of young-old patients and old-old patients were compared.
Results: Of the 105 elderly patientsconfirmed withCOVID-19, 81.0% were young-old patients, and 19.0% were old-old patients; 54.3% of elderly patients were females. Overall, 69.5% of elderly patients had underlying diseases, and the most common comorbidities included hypertension (43.8%), diabetes (25.7%), and cardiac disease (16.2%). Of the elderly patients, 22.9% were severe and 10.5% were critical severe cases. On admission, the most frequent symptoms in elderly patients included fever (66.7%), cough (64.8%), and fatigue (33.3%). Lymphopenia (31.4%), increased D-dimer (38.1%), depressed albumin (36.2%), elevated lactate dehydrogenase (41.0%), and a high level of C-reactive protein (79.0%) were common among elderly patients with COVID-19. The median prothrombin time (PT) and the activated partial thromboplastin time (APTT) were longer in old-old patients than young-old patients (PT median 12.3 vs. 13.1 s, p = 0.007; APTT median 39.0 vs. 33.5 s, p = 0.045). Young-old patients showed fewer complications (14.1%) than old-old patients (40.0%; p = 0.0014) and fewer received invasive ventilator support (3.5 vs. 25.0%, p = 0.006). As of March 11, 2020, 85.7% of elderly patients had been discharged, 3 deaths had occurred, and 11.4% were still hospitalized.
Conclusions: Elderly patients usually have chronic medical illness and are likely to have a severe or critically severe condition. They could show atypical symptoms without fever or cough and multiple organ dysfunction. Old-old patients tend to have more complications than young-old patients during hospitalization. Careful nursing, observation, and systemic treatment are very important in elderly patients.
Keywords: Coronavirus disease 2019; Elderly; Epidemiology; Older people; SARS-CoV-2.
. 2020 May 29;1-9.
doi: 10.1159/000508734. Online ahead of print.
Clinical Characteristics of Elderly Patients With COVID-19 in Hunan Province, China: A Multicenter, Retrospective Study
Ting Guo[SUP] 1 2 3 [/SUP], Qinxue Shen[SUP] 1 2 3 [/SUP], Wei Guo[SUP] 1 2 3 [/SUP], Wenlong He[SUP] 1 2 3 [/SUP], Jinhua Li[SUP] 1 2 3 [/SUP], Yi Zhang[SUP] 1 2 3 [/SUP], Yunnian Wang[SUP] 4 [/SUP], Zhiguo Zhou[SUP] 5 [/SUP], Dingding Deng[SUP] 6 [/SUP], Xiaoli Ouyang[SUP] 1 2 3 [/SUP], Zhi Xiang[SUP] 7 [/SUP], Minyan Jiang[SUP] 8 [/SUP], Minyong Liang[SUP] 9 [/SUP], Peng Huang[SUP] 10 [/SUP], Zaimei Peng[SUP] 11 [/SUP], Xudong Xiang[SUP] 11 [/SUP], Wenlong Liu[SUP] 12 [/SUP], Hong Luo[SUP] 1 2 3 [/SUP], Ping Chen[SUP] 1 2 3 [/SUP], Hong Peng[SUP] 13 14 15 [/SUP]
Affiliations
- PMID: 32474561
- DOI: 10.1159/000508734
Abstract
Background: The aim of this study was to analyze and summarize the clinical characteristics of elderly patients with coronavirus disease 2019 (COVID-19) and compare the differences of young-old patients (60-74 years old) and old-old patients (≥75 years old).
Methods: In thisretrospective, multicenter study, the medical records of elderly patients who were diagnosed with COVID-19 in Hunan province, China, from January 21 to February 19, 2020 were reviewed. The characteristics of young-old patients and old-old patients were compared.
Results: Of the 105 elderly patientsconfirmed withCOVID-19, 81.0% were young-old patients, and 19.0% were old-old patients; 54.3% of elderly patients were females. Overall, 69.5% of elderly patients had underlying diseases, and the most common comorbidities included hypertension (43.8%), diabetes (25.7%), and cardiac disease (16.2%). Of the elderly patients, 22.9% were severe and 10.5% were critical severe cases. On admission, the most frequent symptoms in elderly patients included fever (66.7%), cough (64.8%), and fatigue (33.3%). Lymphopenia (31.4%), increased D-dimer (38.1%), depressed albumin (36.2%), elevated lactate dehydrogenase (41.0%), and a high level of C-reactive protein (79.0%) were common among elderly patients with COVID-19. The median prothrombin time (PT) and the activated partial thromboplastin time (APTT) were longer in old-old patients than young-old patients (PT median 12.3 vs. 13.1 s, p = 0.007; APTT median 39.0 vs. 33.5 s, p = 0.045). Young-old patients showed fewer complications (14.1%) than old-old patients (40.0%; p = 0.0014) and fewer received invasive ventilator support (3.5 vs. 25.0%, p = 0.006). As of March 11, 2020, 85.7% of elderly patients had been discharged, 3 deaths had occurred, and 11.4% were still hospitalized.
Conclusions: Elderly patients usually have chronic medical illness and are likely to have a severe or critically severe condition. They could show atypical symptoms without fever or cough and multiple organ dysfunction. Old-old patients tend to have more complications than young-old patients during hospitalization. Careful nursing, observation, and systemic treatment are very important in elderly patients.
Keywords: Coronavirus disease 2019; Elderly; Epidemiology; Older people; SARS-CoV-2.