tetano
Editor, Senior Moderator
Genomics
. 2020 Oct 10;S0888-7543(20)31961-3.
doi: 10.1016/j.ygeno.2020.10.002. Online ahead of print.
Analysis of the circRNAs expression profile in mouse lung with H7N9 influenza A virus infection
Zhiyuan Liu[SUP] 1 [/SUP], Yanna Guo[SUP] 1 [/SUP], Lingcai Zhao[SUP] 1 [/SUP], Qingzheng Liu[SUP] 1 [/SUP], Miao Tian[SUP] 1 [/SUP], Nan Huang[SUP] 1 [/SUP], Menglu Fan[SUP] 1 [/SUP], Mengqi Yu[SUP] 1 [/SUP], Huizhi Xia[SUP] 1 [/SUP], JiHui Ping[SUP] 2 [/SUP]
Affiliations
Abstract
Influenza A virus is a single-stranded RNA virus that can cause great mortality and economic loss worldwide. Circular RNAs (circRNAs) are non-coding RNAs that have been shown to have important functions in the regulation of biological processes. However, their functions during the influenza A virus infection process remain unclear. Herein, RNA sequencing technology was used to identify circRNAs expressed in mouse lungs during infection with H7N9/PB2-627 K/701D (H7N9/Wild-type) virus and PB2 mutant viruses (H7N9/PB2-627E/701D and H7N9/PB2-627E/701 N). We identified 7126 circRNAs at different genomic locations during H7N9 influenza virus and its mutant virus infections, of which 186 were differentially expressed. Enrichment analysis revealed that the differentially expressed circRNAs were associated with the viral infection process. Our study shows that circRNA expression profiles were altered following H7N9 influenza A virus infection and the differentially expressed circRNAs may have an important immune-regulating function during viral infection.
Keywords: H7N9; Infection; Influenza a virus; RNA-seq; circRNAs.
. 2020 Oct 10;S0888-7543(20)31961-3.
doi: 10.1016/j.ygeno.2020.10.002. Online ahead of print.
Analysis of the circRNAs expression profile in mouse lung with H7N9 influenza A virus infection
Zhiyuan Liu[SUP] 1 [/SUP], Yanna Guo[SUP] 1 [/SUP], Lingcai Zhao[SUP] 1 [/SUP], Qingzheng Liu[SUP] 1 [/SUP], Miao Tian[SUP] 1 [/SUP], Nan Huang[SUP] 1 [/SUP], Menglu Fan[SUP] 1 [/SUP], Mengqi Yu[SUP] 1 [/SUP], Huizhi Xia[SUP] 1 [/SUP], JiHui Ping[SUP] 2 [/SUP]
Affiliations
- PMID: 33049361
- DOI: 10.1016/j.ygeno.2020.10.002
Abstract
Influenza A virus is a single-stranded RNA virus that can cause great mortality and economic loss worldwide. Circular RNAs (circRNAs) are non-coding RNAs that have been shown to have important functions in the regulation of biological processes. However, their functions during the influenza A virus infection process remain unclear. Herein, RNA sequencing technology was used to identify circRNAs expressed in mouse lungs during infection with H7N9/PB2-627 K/701D (H7N9/Wild-type) virus and PB2 mutant viruses (H7N9/PB2-627E/701D and H7N9/PB2-627E/701 N). We identified 7126 circRNAs at different genomic locations during H7N9 influenza virus and its mutant virus infections, of which 186 were differentially expressed. Enrichment analysis revealed that the differentially expressed circRNAs were associated with the viral infection process. Our study shows that circRNA expression profiles were altered following H7N9 influenza A virus infection and the differentially expressed circRNAs may have an important immune-regulating function during viral infection.
Keywords: H7N9; Infection; Influenza a virus; RNA-seq; circRNAs.