tetano
Editor, Senior Moderator
Vaccine. 2014 Mar 5. pii: S0264-410X(14)00229-1. doi: 10.1016/j.vaccine.2014.02.044. [Epub ahead of print]
General practice encounters following seasonal influenza vaccination as a proxy measure of early-onset adverse events.
Dey A1, Gidding HF2, Menzies R3, McIntyre P4.
Author information
Abstract
BACKGROUND:
In 2010, use of seasonal trivalent influenza vaccine (TIV) in children <5 years of age was suspended in Australia following reports of vaccine-related febrile convulsions. We investigated the utility of data on primary care [general practice (GP)] consultations for any reason within three days of receipt of influenza vaccine as recorded on the Australian Childhood Immunisation Register (ACIR) as a means of signal detection.
METHODS:
Data on GP consultations were obtained from Medicare Australia (Australian Government Department of Human Services) for children recorded on the ACIR as receiving either TIV or monovalent influenza vaccine. Rates of GP consultation by day following ACIR-recorded receipt of influenza vaccine were compared by year (2008-2010), vaccine type, age and region.
RESULTS:
In 2010, GP encounter rates on the day after receipt of the TIV manufactured by bioCSL (formerly CSL Biotherapies (Fluvax?) were significantly higher than both bioCSL TIVs in the previous two years [rate ratio (RR) 1.9; 95% CI: 1.7-2.2] and Sanofi Pasteur TIV, Vaxigrip? [RR 1.6, 95% CI 1.4-1.7] in 2009-2010. Encounter rates were also higher than for CSL Monovalent influenza vaccine, Panvax? [RR 1.9, 95% CI 1.7-2.2] in 2009-2010. These findings were robust to adjustment for age group (≤2, >2 years) and region (Western Australia vs other Australian states/territories).
CONCLUSIONS:
A primary care consultation on the day after vaccine receipt is a reasonable proxy for early reactogenicity and has potential for use in various settings.
Copyright ? 2014. Published by Elsevier Ltd.
KEYWORDS:
Adverse events, General practice, Influenza, Primary care
PMID:
24613527
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24613527
General practice encounters following seasonal influenza vaccination as a proxy measure of early-onset adverse events.
Dey A1, Gidding HF2, Menzies R3, McIntyre P4.
Author information
Abstract
BACKGROUND:
In 2010, use of seasonal trivalent influenza vaccine (TIV) in children <5 years of age was suspended in Australia following reports of vaccine-related febrile convulsions. We investigated the utility of data on primary care [general practice (GP)] consultations for any reason within three days of receipt of influenza vaccine as recorded on the Australian Childhood Immunisation Register (ACIR) as a means of signal detection.
METHODS:
Data on GP consultations were obtained from Medicare Australia (Australian Government Department of Human Services) for children recorded on the ACIR as receiving either TIV or monovalent influenza vaccine. Rates of GP consultation by day following ACIR-recorded receipt of influenza vaccine were compared by year (2008-2010), vaccine type, age and region.
RESULTS:
In 2010, GP encounter rates on the day after receipt of the TIV manufactured by bioCSL (formerly CSL Biotherapies (Fluvax?) were significantly higher than both bioCSL TIVs in the previous two years [rate ratio (RR) 1.9; 95% CI: 1.7-2.2] and Sanofi Pasteur TIV, Vaxigrip? [RR 1.6, 95% CI 1.4-1.7] in 2009-2010. Encounter rates were also higher than for CSL Monovalent influenza vaccine, Panvax? [RR 1.9, 95% CI 1.7-2.2] in 2009-2010. These findings were robust to adjustment for age group (≤2, >2 years) and region (Western Australia vs other Australian states/territories).
CONCLUSIONS:
A primary care consultation on the day after vaccine receipt is a reasonable proxy for early reactogenicity and has potential for use in various settings.
Copyright ? 2014. Published by Elsevier Ltd.
KEYWORDS:
Adverse events, General practice, Influenza, Primary care
PMID:
24613527
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24613527