tetano
Editor, Senior Moderator
Front Pediatr
. 2024 Oct 23:12:1418499.
doi: 10.3389/fped.2024.1418499. eCollection 2024. Clinical characteristics of severe influenza as a risk factor for febrile seizures in children: a retrospective analysis
Peng Li[SUP] 1 2 [/SUP], Mei Chen[SUP] 1 2 [/SUP], Daobin Wang[SUP] 3 [/SUP], Xue Zhang[SUP] 1 [/SUP], Ruiyang Sun[SUP] 1 [/SUP], Wanyu Jia[SUP] 1 [/SUP], Shuqin Fu[SUP] 1 [/SUP], Junhao Cui[SUP] 1 [/SUP], Chunlan Song[SUP] 1 2 [/SUP]
Affiliations
Objective: To retrospectively analyze the clinical characteristics and independent risk factors of severe influenza combined with febrile seizures, and to provide more basis for early clinical intervention.
Methods: A total of 161 children with severe influenza were collected as study subjects and divided into convulsive (FC) group (40 cases) and non-convulsive (NFC) group (121 cases) according to whether they had febrile seizures. The demographic characteristics and clinical data of the two groups were analyzed. Multivariate logistic regression was used to analyze the risk factors of severe influenza combined with febrile seizures. The predictive efficacy was evaluated by receiver operating characteristic (ROC) curve analysis.
Results: (1) Multiple logistic regression analysis revealed that C-reactive protein (CRP) levels, Serum interleukin 6 (IL-6) levels, Days from onset of Flu symptoms to hospitalization, cerebrospinal fluid protein (CSF-TP) levels and the influenza virus type A (FluA) infection rate were found to be independent risk factors for severe influenza combined with febrile seizures in children. (2) ROC curve analysis showed that the cut-off value of CRP, Serum IL-6, Days from onset of Flu symptoms to hospitalization and CSF-TP were 7.57 mg/L, 9.84 pg/ml, 4.5 days and 194.8 mg/L, respectively.
Conclusion: Children with severe influenza with CRP ≥ 7.57 mg/L, Serum IL-6 ≥ 9.84 pg/ml, Days from onset of Flu symptoms to hospitalization ≤4.5 days, CSF-TP ≥ 194.8 mg/L and FluA had a significantly increased risk of febrile seizures. It is useful for clinicians to determine the risk of severe influenza combined with febrile seizures, to adjust the early treatment plan, and to reduce the incidence of critically ill patients.
Keywords: febrile seizures; influenza; multivariate logistic regression; receiver operating characteristic curve; risk factors.
. 2024 Oct 23:12:1418499.
doi: 10.3389/fped.2024.1418499. eCollection 2024. Clinical characteristics of severe influenza as a risk factor for febrile seizures in children: a retrospective analysis
Peng Li[SUP] 1 2 [/SUP], Mei Chen[SUP] 1 2 [/SUP], Daobin Wang[SUP] 3 [/SUP], Xue Zhang[SUP] 1 [/SUP], Ruiyang Sun[SUP] 1 [/SUP], Wanyu Jia[SUP] 1 [/SUP], Shuqin Fu[SUP] 1 [/SUP], Junhao Cui[SUP] 1 [/SUP], Chunlan Song[SUP] 1 2 [/SUP]
Affiliations
- PMID: 39507495
- PMCID: PMC11537893
- DOI: 10.3389/fped.2024.1418499
Objective: To retrospectively analyze the clinical characteristics and independent risk factors of severe influenza combined with febrile seizures, and to provide more basis for early clinical intervention.
Methods: A total of 161 children with severe influenza were collected as study subjects and divided into convulsive (FC) group (40 cases) and non-convulsive (NFC) group (121 cases) according to whether they had febrile seizures. The demographic characteristics and clinical data of the two groups were analyzed. Multivariate logistic regression was used to analyze the risk factors of severe influenza combined with febrile seizures. The predictive efficacy was evaluated by receiver operating characteristic (ROC) curve analysis.
Results: (1) Multiple logistic regression analysis revealed that C-reactive protein (CRP) levels, Serum interleukin 6 (IL-6) levels, Days from onset of Flu symptoms to hospitalization, cerebrospinal fluid protein (CSF-TP) levels and the influenza virus type A (FluA) infection rate were found to be independent risk factors for severe influenza combined with febrile seizures in children. (2) ROC curve analysis showed that the cut-off value of CRP, Serum IL-6, Days from onset of Flu symptoms to hospitalization and CSF-TP were 7.57 mg/L, 9.84 pg/ml, 4.5 days and 194.8 mg/L, respectively.
Conclusion: Children with severe influenza with CRP ≥ 7.57 mg/L, Serum IL-6 ≥ 9.84 pg/ml, Days from onset of Flu symptoms to hospitalization ≤4.5 days, CSF-TP ≥ 194.8 mg/L and FluA had a significantly increased risk of febrile seizures. It is useful for clinicians to determine the risk of severe influenza combined with febrile seizures, to adjust the early treatment plan, and to reduce the incidence of critically ill patients.
Keywords: febrile seizures; influenza; multivariate logistic regression; receiver operating characteristic curve; risk factors.