tetano
Editor, Senior Moderator
Front Pediatr
. 2023 May 18;11:1167871.
doi: 10.3389/fped.2023.1167871. eCollection 2023. Characteristics and outcomes of multisystem inflammatory syndrome in children: A multicenter, retrospective, observational cohort study in Mexico
Marco Antonio Yamazaki-Nakashimada[SUP] 1 [/SUP], Horacio Márquez-González[SUP] 2 [/SUP], Guadalupe Miranda-Novales[SUP] 3 [/SUP], Gonzalo Antonio Neme Díaz[SUP] 4 [/SUP], Sandhi Anel Prado Duran[SUP] 5 [/SUP], Antonio Luévanos Velázquez[SUP] 6 [/SUP], Maria F Castilla-Peon[SUP] 7 [/SUP], Nadia González-García[SUP] 2 [/SUP], Miguel Alejandro Sánchez Duran[SUP] 1 [/SUP], Martha Patricia Márquez Aguirre[SUP] 1 [/SUP], Miguel Angel Villasis-Keever[SUP] 3 [/SUP], Ranferi Aragón Nogales[SUP] 3 [/SUP], Juan Carlos Núñez-Enríquez[SUP] 3 [/SUP], Maria Elena Martinez Bustamante[SUP] 8 [/SUP], Carlos Aguilar Argüello[SUP] 4 [/SUP], Jesús Ramírez de Los Santos[SUP] 4 [/SUP], Alejandra Pérez Barrera[SUP] 4 [/SUP], Lourdes Anais Palacios Cantú[SUP] 5 [/SUP], Jesús Membrila Mondragón[SUP] 5 [/SUP], Paloma Vizcarra Alvarado[SUP] 6 [/SUP], Rodolfo Norberto Jiménez Juárez[SUP] 2 [/SUP], Víctor Olivar López[SUP] 2 [/SUP], Roberto Velasco-Segura[SUP] 9 [/SUP], Adrián López Chávez[SUP] 2 [/SUP]
Affiliations
Introduction: Multisystem inflammatory syndrome in children associated with coronavirus disease 2019 (MIS-C), a novel hyperinflammatory condition secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is associated with severe outcomes such as coronary artery aneurysm and death.
Methods: This multicenter, retrospective, observational cohort study including eight centers in Mexico, aimed to describe the clinical characteristics and outcomes of patients with MIS-C. Patient data were evaluated using latent class analysis (LCA) to categorize patients into three phenotypes: toxic shock syndrome-like (TSSL)-MIS-C, Kawasaki disease-like (KDL)-MIS-C, and nonspecific MIS-C (NS-MIS-C). Risk factors for adverse outcomes were estimated using multilevel mixed-effects logistic regression.
Results: The study included 239 patients with MIS-C, including 61 (26%), 70 (29%), and 108 (45%) patients in the TSSL-MIS-C, KDL-MIS-C, and NS-MIS-C groups, respectively. Fifty-four percent of the patients were admitted to the intensive care unit, and 42%, 78%, and 41% received intravenous immunoglobulin, systemic glucocorticoids, and anticoagulants, respectively. Coronary artery dilatation and aneurysms were found in 5.7% and 13.2% of the patients in whom coronary artery diameter was measured, respectively. Any cause in-hospital mortality was 5.4%. Hospitalization after ten days of symptoms was associated with coronary artery abnormalities (odds ratio [OR] 1.6, 95% confidence interval [CI] 1.2-2.0). Age ≥10 years (OR: 5.6, 95% CI: 1.4-2.04), severe underlying condition (OR: 9.3, 95% CI: 2.8-31.0), platelet count <150,000 /mm[SUP]3[/SUP] (OR: 4.2, 95% CI: 1.2-14.7), international normalized ratio >1.2 (OR: 3.8, 95% CI: 1.05-13.9), and serum ferritin concentration >1,500 mg/dl at admission (OR: 52, 95% CI: 5.9-463) were risk factors for death.
Discussion: Mortality in patients with MIS-C was higher than reported in other series, probably because of a high rate of cases with serious underlying diseases.
Keywords: Mexico; coronary aneurism; coronavirus disease (COVID)-19; multicenter study; multisystem inflammatory syndrome; pediatric; severe acute respiratory syndrome coronavirus (SARS-CoV).
. 2023 May 18;11:1167871.
doi: 10.3389/fped.2023.1167871. eCollection 2023. Characteristics and outcomes of multisystem inflammatory syndrome in children: A multicenter, retrospective, observational cohort study in Mexico
Marco Antonio Yamazaki-Nakashimada[SUP] 1 [/SUP], Horacio Márquez-González[SUP] 2 [/SUP], Guadalupe Miranda-Novales[SUP] 3 [/SUP], Gonzalo Antonio Neme Díaz[SUP] 4 [/SUP], Sandhi Anel Prado Duran[SUP] 5 [/SUP], Antonio Luévanos Velázquez[SUP] 6 [/SUP], Maria F Castilla-Peon[SUP] 7 [/SUP], Nadia González-García[SUP] 2 [/SUP], Miguel Alejandro Sánchez Duran[SUP] 1 [/SUP], Martha Patricia Márquez Aguirre[SUP] 1 [/SUP], Miguel Angel Villasis-Keever[SUP] 3 [/SUP], Ranferi Aragón Nogales[SUP] 3 [/SUP], Juan Carlos Núñez-Enríquez[SUP] 3 [/SUP], Maria Elena Martinez Bustamante[SUP] 8 [/SUP], Carlos Aguilar Argüello[SUP] 4 [/SUP], Jesús Ramírez de Los Santos[SUP] 4 [/SUP], Alejandra Pérez Barrera[SUP] 4 [/SUP], Lourdes Anais Palacios Cantú[SUP] 5 [/SUP], Jesús Membrila Mondragón[SUP] 5 [/SUP], Paloma Vizcarra Alvarado[SUP] 6 [/SUP], Rodolfo Norberto Jiménez Juárez[SUP] 2 [/SUP], Víctor Olivar López[SUP] 2 [/SUP], Roberto Velasco-Segura[SUP] 9 [/SUP], Adrián López Chávez[SUP] 2 [/SUP]
Affiliations
- PMID: 37274824
- PMCID: PMC10233130
- DOI: 10.3389/fped.2023.1167871
Introduction: Multisystem inflammatory syndrome in children associated with coronavirus disease 2019 (MIS-C), a novel hyperinflammatory condition secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is associated with severe outcomes such as coronary artery aneurysm and death.
Methods: This multicenter, retrospective, observational cohort study including eight centers in Mexico, aimed to describe the clinical characteristics and outcomes of patients with MIS-C. Patient data were evaluated using latent class analysis (LCA) to categorize patients into three phenotypes: toxic shock syndrome-like (TSSL)-MIS-C, Kawasaki disease-like (KDL)-MIS-C, and nonspecific MIS-C (NS-MIS-C). Risk factors for adverse outcomes were estimated using multilevel mixed-effects logistic regression.
Results: The study included 239 patients with MIS-C, including 61 (26%), 70 (29%), and 108 (45%) patients in the TSSL-MIS-C, KDL-MIS-C, and NS-MIS-C groups, respectively. Fifty-four percent of the patients were admitted to the intensive care unit, and 42%, 78%, and 41% received intravenous immunoglobulin, systemic glucocorticoids, and anticoagulants, respectively. Coronary artery dilatation and aneurysms were found in 5.7% and 13.2% of the patients in whom coronary artery diameter was measured, respectively. Any cause in-hospital mortality was 5.4%. Hospitalization after ten days of symptoms was associated with coronary artery abnormalities (odds ratio [OR] 1.6, 95% confidence interval [CI] 1.2-2.0). Age ≥10 years (OR: 5.6, 95% CI: 1.4-2.04), severe underlying condition (OR: 9.3, 95% CI: 2.8-31.0), platelet count <150,000 /mm[SUP]3[/SUP] (OR: 4.2, 95% CI: 1.2-14.7), international normalized ratio >1.2 (OR: 3.8, 95% CI: 1.05-13.9), and serum ferritin concentration >1,500 mg/dl at admission (OR: 52, 95% CI: 5.9-463) were risk factors for death.
Discussion: Mortality in patients with MIS-C was higher than reported in other series, probably because of a high rate of cases with serious underlying diseases.
Keywords: Mexico; coronary aneurism; coronavirus disease (COVID)-19; multicenter study; multisystem inflammatory syndrome; pediatric; severe acute respiratory syndrome coronavirus (SARS-CoV).